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Pharmaceutical composition having target organ protection function and usage thereof

A composition and drug technology, applied in the field of pharmacy, can solve the problems of prevention or treatment of cardiovascular events, etc.

Inactive Publication Date: 2007-05-30
深圳市奥萨药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The target organ damage of patients needs further control and intervention, and the prevention or treatment of cardiovascular events has not yet been verified by clinical data [Wilson, et al. Amlodipine / Atorvastatin (Caduet) for Preventing Heart Disease. American Family Physician, 2006, 73 (6): 1067-1068]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Example 1 Preparation of compound amlodipine / atorvastatin / folic acid tablet

[0104] The prescription is as follows (1000 tablets):

[0105] Amlodipine 5g

[0106] Atorvastatin 10g

[0107] Folic acid 0.2g

[0108] Sodium carboxymethyl starch 20g

[0109] Calcium hydrogen phosphate 180g

[0110] 10% povidone aqueous solution appropriate amount

[0111] Magnesium Stearate 1%

[0112] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take amlodipine besylate, 10 g of atorvastatin and 0.2 g of folic acid equivalent to 5 g of amlodipine and mix evenly according to the method of equal increase, add 20 g of sodium carboxymethyl starch and 180 g of calcium hydrogen phosphate, and increase according to the same amount Dissolve folic acid in 10% povidone aqueous solution of adhesive, add appropriate amount of adhesive to make soft material, granulate with 30 mesh, dry at 40-45°C for 3 hours; granulate with 30 mesh, ...

Embodiment 2

[0113] Embodiment 2 prepares compound tablet

[0114] Preparation method: the same as in Example 1. The ingredients and contents of the 15 drug compounds are shown in Table 9.

[0115] Table 9 Composition of 15 compound active drug formulations

[0116] compound type

[0117] Note: dosage of amlodipine salt=dose shown in the table×(molecular weight of amlodipine salt / molecular weight of amlodipine); when preparing medicine by 1000 tablets / grain / bag, dosage=dose shown in the table× 1000.

Embodiment 3

[0118] Example 3 Preparation of Compound Amlodipine / Atorvastatin / Folic Acid Capsules

[0119] The prescription is as follows (1000 capsules):

[0120] Amlodipine 5g

[0121] Atorvastatin 10g

[0122] Folic acid 0.2g

[0123] Lactose 100~200g

[0124] Sodium carboxymethyl starch 15~25g

[0125] 10% povidone aqueous solution appropriate amount

[0126] Magnesium Stearate 1%

[0127] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take amlodipine maleate, 10 g of atorvastatin and 0.2 g of folic acid equivalent to 5 g of amlodipine and mix uniformly according to the method of equal increments, add 100-200 g of lactose, 15-25 g of sodium carboxymethyl starch (excipients are exact The dosage is adjusted according to the dosage of the active drug), uniformly mixed according to the method of equal increase, made into a soft material with 10% povidone ethanol solution, granulated with a 20-mesh sieve, dried at 60°C for a...

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PUM

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Abstract

The invention discloses an isallobaric antihyperglycemic drug composition, which comprises the following parts: amipramizide, autolmvastatin, acidum folicum or calcium folinate or left-handed calcium folinate and acceptable carrier. The invention possesses obvious synergic action, which protects endothelial cell, heart and the kidney or reduces sudden death for brain.

Description

technical field [0001] The invention relates to an antihypertensive and lipid-lowering pharmaceutical composition with target organ protection effect and application thereof, belonging to the field of pharmacy. Background technique [0002] Cardiovascular disease is one of the main causes of human death, mainly coronary heart disease and stroke. Three major risk factors for cardiovascular disease have been identified: dyslipidemia, including high low-density lipoprotein cholesterol (LDL-C), high triglycerides, and low high-density lipoprotein cholesterol (HDL-C); high blood pressure; smoking . Studies have shown that 80-90% of patients with coronary heart disease have at least one of these three risk factors. Other risk factors include age (≥55 years), male sex, history of stroke, peripheral artery disease, diabetes, proteinuria, left ventricular hypertrophy, and family history of coronary heart disease. Risk factors for cardiovascular disease rarely occur alone, but ofte...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K9/16A61K9/20A61K9/48A61P3/06A61P9/12A61P9/10A61P9/06A61P9/04A61P9/00A61P13/12A61P27/02A61K31/4422A61K31/401
Inventor 徐希平陈光亮王琳琳王燕于多李华王文艳陈明侠
Owner 深圳市奥萨药业有限公司
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