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Antivirus compound formulation, preparation process, quality control method and use thereof

A compound preparation and anti-viral technology, which is applied in anti-viral agents, pill delivery, pharmaceutical formulations, etc., can solve the problems of slow onset of action, complex ingredients, and large dosage of drugs for patients

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many medicines for treating colds on the market, Western medicines generally have the problem of large side effects, while Chinese patent medicines are medicines that are used to treat diseases according to different causes and combined with TCM theory, such as wind-cold cold, wind-heat cold, etc. choose different drugs for treatment
Moreover, there are disadvantages such as dizziness, drowsiness, and weakness of limbs in Western medicine cold medicines currently on the market; while pure Chinese medicine cold medicines have disadvantages such as slow onset of action.
In order to achieve better prevention and control purposes, many inventors and pharmaceutical companies have done a lot of research, and also provided some excellent therapeutic products; such as: patent application number: 200410048399.7, named "an antiviral orally disintegrating tablet and Its preparation method" patent application, it is used for cold diseases and has a quick effect; but in-depth research has found that the use of large prescriptions with many medicinal flavors has complicated ingredients in the preparation, and the patient takes a large amount of medicine. On this basis, the applicant has adopted the compatibility of Scutellaria baicalensis, Epimedium and Houttuynia cordata monomers, which can not only reduce the dosage of patients, but also remove some components with strong toxic and side effects in the extracts of medicinal materials, and improve the safety and quality of the preparation. The controllability greatly improves the curative effect, and is more conducive to the molding of preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1 of the present invention: baicalin 50g icariin 25g houttuyonin sodium 25g

[0060] Take the above drug, add 1800ml of water for injection, add mannitol according to the dosage ratio of drug and excipient 1:2, adjust the pH value to 6.0-8.0 with saturated sodium hydroxide solution, add water for injection to 2000ml, mix well, and add 0.5% injection Use activated carbon, boil for 40 minutes, coarse filter, then filter with 0.45μm and 0.22μm microporous membranes, divide the filtrate, 2.0ml per bottle, freeze-dry, the equilibrium time of the first stage when the freezing temperature is 0°C 3 hours, that is, the time when the shelf temperature is basically the same as the product temperature; when the freezing temperature in the second stage is from 0°C to the lowest eutectic temperature -20°C, the equilibrium time between the shelf temperature and the product temperature is 2.5 hours; the third stage continues It takes about 3.5 hours to cool down to -30°C, ke...

Embodiment 2

[0064] Embodiment 2 of the present invention: baicalin 50g icariin 25g neohouttuydin sodium 25g

[0065] Mix the above drugs, add 5% citric acid, 20% mannitol, and 25% polyvinylpyrrolidone K30, pass through a 30-mesh sieve, add appropriate amount of talcum powder and micropowder silica gel, mix evenly, and press into tablets to obtain sublingual buccal tablets .

[0066] Among them, baicalin is commercially available or obtained by the following method: Scutellaria baicalensis is crushed, 8 times the volume of 70% ethanol is added to reflux and extracted 3 times, each time for 1 hour, the extracts are combined, filtered, the filtrate is decompressed to recover ethanol, concentrated to 60 Measure the relative density at ℃ to 1.05-1.15, add 3 times the volume of water to dissolve, filter, pass the filtrate through the AB-8 macroporous resin column, first wash with 6 times of water and 5 times of 20% ethanol, and discard the eluent; Desorb with 60% ethanol, collect the desorbed ...

Embodiment 3

[0069] Embodiment 3 of the present invention: Baicalin 40g Icariin 60g

[0070] Take the above drug and add 1800ml water for injection, add mannitol according to the dosage ratio of drug and excipient 1:2, adjust the pH value to 6.0-8.0 with saturated sodium hydroxide solution, add water for injection to 2000ml, mix well, add 0.5% injection Activated carbon, boiled for 40 minutes, coarsely filtered, and then filtered with 0.45 μm and 0.22 μm microporous membranes, the filtrate was divided into 2.0ml bottles, freeze-dried, and the equilibrium time of the first stage when the freezing temperature was 0°C was 3 hours, that is, the time when the shelf temperature is basically consistent with the product temperature; in the second stage, when the freezing temperature is from 0°C to the lowest eutectic temperature -20°C, the equilibrium time between the shelf temperature and product temperature is 2.5 hours; the third stage continues to cool down It takes about 3.5 hours to reach -3...

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PUM

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Abstract

The invention discloses a compound preparation which comprises two or more of extracts of baikal skullcap root glycosides, barren wort glycosides, houttuynine sodium bisulfite or houttuyninum, and can be prepared into injections, capsules, tablets, dispersible tablets, sublingual tablets, granules, oral liquid preparations, drop pills and other pharmacologically allowable dose forms. The invention can be applied to the treatment of pneumonia, respiratory tract infection, influenza, avian Influenza, SARS and asthma.

Description

technical field [0001] The invention relates to an antiviral compound preparation and its preparation method, quality control method and application, belonging to the technical field of traditional Chinese medicine. technical background [0002] A cold is an upper respiratory tract infection caused by a variety of viruses, commonly known as "cold", and is a common respiratory disease that can occur in all seasons. Viral influenza is upper respiratory tract infection, also referred to as upper flu, which is a common respiratory infectious disease caused by multiple viruses. Although there are many medicines for treating colds on the market, Western medicines generally have the problem of large side effects, while Chinese patent medicines are medicines that are used to treat diseases according to different causes and combined with TCM theory, such as wind-cold cold, wind-heat cold, etc. Choose different drugs for treatment. Moreover, there are disadvantages such as dizziness...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/78A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61P31/14A61P11/00A61P37/04
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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