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Pharmaceutical composition of Silibinin and isatis root

A technology of extracts of silibinin and Radix isatidis, which is applied in the field of medicine and achieves the effects of ensuring safety, stabilizing various indicators, and regenerating jaundice and hepatocytes.

Inactive Publication Date: 2007-05-30
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, using the interaction between silibinin or its derivatives and Radix Radix or its extracts, compatible prescriptions, drugs for the treatment of hepatitis, have not yet been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] The preparation of embodiment 1 isatidis extract

[0143] Preparation method of isatidis extract

[0144] Take Radix Radix, crush it into coarse powder, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.15-1.20 concentrate, add 1% hydrochloric acid to adjust When the pH value reaches 5-6, add it to a strongly acidic cation exchange resin column, add 2 times the amount of water to flush the column, discard the flushing solution, add 1% ammonia test solution to the column, collect the eluent, and then add 1% hydrochloric acid Adjust the pH value to 7-7.5, let stand overnight, filter, concentrate, and dry to obtain the product.

[0145] Identification experiment of Banlangen extract

[0146] Take 0.1g of this product, add 10ml of ethanol, sonicate for 15min, evaporate to dryness, add 1ml of ethanol to the residue to dissolve, and use it as the test s...

Embodiment 2

[0153] The preparation of embodiment 2 SHB composition tablet

[0154] 1. Prescription:

[0155] SHB Composition Prescription 1

[0156] Silybin Meglumine 100g

[0157] Radix Radix Radix Extract 112g is equivalent to 8kg of raw medicinal materials

[0158] Starch 120.0g

[0159] Microcrystalline Cellulose 40.0g

[0160] 2% HPMC aqueous solution appropriate amount

[0161] Magnesium Stearate 2.0g

[0162] Sodium starch glycolate 4.0g

[0163]

[0164] A total of 1000 tablets were prepared

[0165] SHB Composition Prescription 2

[0166] Silybin Meglumine 200g

[0167] Radix Radix Radix Extract 7g is equivalent to 500g of raw medicinal materials

[0168] Starch 120.0g

[0169] Microcrystalline Cellulose 40.0g

[0170] 2% HPMC aqueous solution appropriate amount

[0171] Magnesium Stearate 2.0g

[0172] Sodium starch glycolate 4.0g

[0173]

[0174] A total of 1...

Embodiment 3

[0206] The preparation of embodiment 3 SHB composition capsules

[0207] 1. Prescription:

[0208] SHB Composition Prescription 1

[0209] Silybin Meglumine 200g

[0210] Radix Radix Radix Extract 14g is equivalent to 1000g of raw medicinal materials

[0211] Starch 60.0g

[0212] Microcrystalline Cellulose 20.0g

[0213] 2% HPMC aqueous solution appropriate amount

[0214] Magnesium Stearate 1.0g

[0215]

[0216] A total of 1000 capsules were prepared

[0217] SHB Composition Prescription 2

[0218] Silybin Meglumine 100g

[0219] Radix Radix Radix Extract 112g is equivalent to 8000g of raw medicinal materials

[0220] Starch 60.0g

[0221] Microcrystalline Cellulose 20.0g

[0222] 2% HPMC aqueous solution appropriate amount

[0223] Magnesium Stearate 1.0g

[0224]

[0225] A total of 1000 capsules were prepared

[0226] SHB Composition Prescription 3...

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Abstract

The invention discloses a pharmaceutical composition against hepatitis, its preparing process and use, wherein the composition comprises (by weight ratio) silybin or its derivatives 25-400 parts, radix isatidis 200-20000 parts, or silybin or its derivatives 25-400 parts, radix isatidis extract 1-400 parts. The composition can be prepared into clinically and pharmaceutically acceptable dosage forms having synergic action against hepatitis.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition prepared from silybin or its derivatives and isatidis or its extract, a preparation method thereof, a pharmaceutical composition for treating hepatitis diseases and a preparation thereof, belonging to the technical field of medicine. 2. Background technology [0002] Hepatitis is one of the common serious infectious diseases, among which viral hepatitis is the main one. According to incomplete statistics, currently 8-10% of the Chinese population are carriers of hepatitis B virus, and there are still a considerable number of new patients increasing every year. Viral hepatitis can be divided into types: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Although there are many kinds of drugs for treating liver diseases at present, because the pathogenesis of liver diseases has not been fully elucidated, most of them are drugs that improve liver function, promote liver cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/315A61K36/19A61P1/16A61P31/14A61P31/20A61K31/357
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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