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System and method for processing capacitive signals

a capacitive signal and capacitive technology, applied in the field of sensors, can solve the problems of relatively insensitive electronic sensors and poor performance of acoustic sensors in aqueous environments, and achieve the effects of reducing costs, good electrical interface, and more accurate and sensitive analysis

Inactive Publication Date: 2005-02-24
MOLECULAR REFLECTION DR MICHAEL NERENBERG & DR ROBERT PETCAVICH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The patent describes a new sensor design that can tolerate changes in environmental or system temperature, and can be used in biologic applications. The sensors have a modular construction, which reduces costs. The sensors can detect changes in surface properties of a sensor membrane caused by a binding event, such as a change in mass or pressure. The sensors can be used in various applications, such as in aqueous environments. The sensor assembly is also tolerant to interference from other molecules and can provide accurate and sensitive analysis of changes in frequency shifts. Overall, the patent provides a new sensor design that is better than existing devices for various binding events and can be used in various biologic applications."

Problems solved by technology

Acoustic sensors do not perform well in aqueous environments.
Electronic sensors remain relatively insensitive.

Method used

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  • System and method for processing capacitive signals
  • System and method for processing capacitive signals
  • System and method for processing capacitive signals

Examples

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Effect test

example 1

Use of a Resonant Sensor as a Density Sensor

As described above, the device detects changes in density conferred by concentration of biological molecules in the space above the sensor. Biological molecules such as protein (density 1.3) DNA (density 1.5) and RNA (density 1.7) are substantially higher than that of water (density 1.0). and substantially higher than those of cells (density 1.05-1.09). However, when present in a monolayer, this altered density is barely seen because it only creates a very thin layer of altered density and the net density in the sphere is not substantially changed. The sensitivity of detection of the devices described herein may be amplified by creating a 3 dimensional region of binding (using a hydrogel) which extends farther out into the hemisphere of water interrogated by the resonant membrane. The hydrogel-bonded resonant sensor is prepared as described in U.S. patent application Ser. No. 10 / 306,506 (Atty Docket No. 035300-0502, filed Nov. 26, 2002)....

example 2

Use of a Resonant Sensor to Map Expression of Proteins

Antibodies immobilized to the resonant sensor may be used to map the expression of cellular proteins, much as nucleic acid “chips” currently are used to map the expression of cellular RNAs. In this case, an unlabeled protein extract is applied to a resonant sensor array containing antibodies of interest embedded into a hydrogel. The hydrogel-bonded resonant sensor is prepared as described in U.S. patent application Ser. No. 10 / 306,506 (Atty Docket No. 035300-0502, filed Nov. 26, 2002). These antibodies may detect all forms of the protein, or may be designed to detect specific conformers (e.g. phosphorylated forms). Binding of the protein confers a density shift, which may then be augmented by addition of a mass enhancement reagent. This reagent could be used to distinguish conformational subtypes (e.g. a phosphorylated form as above) or may be a natural dimerization partner. Thus allowing determinations of both structure (total...

example 3

Use of a Resonant Sensor to Assess Enzyme Activities

An array of enzyme substrates is produced by embedding the substrates in a hydrogel. The hydrogel-bonded resonant sensor is prepared as described in U.S. patent application Ser. No. 10 / 306,506 (Atty Docket No. 035300-0502, filed Nov. 26, 2002). The resulting array is contacted with one or more enzymes of interest (e.g., kinases, hydrolases, esterases, etc.) and the resulting modification to each substrate is detected by a mass conferring specificity agent (e.g. a phosphor-tyrosine specific antibody or a phosphor specific chelate. Changes in mass or density within the sensed volume above each sensor in the array are monitored by monitoring resonant frequency of the sensor membrane.

An enzymatic activity sensor as described is used to detect changes in mass conferred by enzymatic addition of mass to a substrate. In the case of DNA assays, the rolling circle, anchored SDA, anchored PCR and anchored NASBA reactions may be monitored ...

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Abstract

A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias. The signals are then processed through an amplifier and a digital signal processor using a modified periodogram.

Description

FIELD OF THE INVENTION The present invention relates to sensors for monitoring a change in force as applied to a surface membrane or a change in the surface properties of the sensor membrane. More particularly, the invention relates to a microfabricated mechanical resonant sensor and a sensor assembly. BACKGROUND The following description is provided to assist the understanding of the reader. None of the information provided or references cited is admitted to be prior art to the present invention. Technological advances in combinatorial chemistry, genomics, and proteomics have fostered an increased need for rapid high throughput (HTP) screening methods able to monitor and / or detect the reaction between one or more target species and binding partners or potential binding partners of such targets. Various systems have been, and are being, explored to detect analytes. Systems such as affinity chemical sensing, arrayed sensors, and acoustic sensors are being investigated for their re...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B06B1/02G01N33/483B81B3/00G01N5/02G01N29/02G01N29/22G01N33/566
CPCB06B1/0292Y10T29/53052G01N29/022G01N29/222G01N29/223G01N2291/014G01N2291/0255G01N2291/0256G01N2291/02818G01N2291/0423G01N2291/0427G01N2291/106Y10T29/49128Y10T29/4913Y10T29/49169Y10T29/49126G01N29/02
Inventor NEBRIGIC, DRAGAN
Owner MOLECULAR REFLECTION DR MICHAEL NERENBERG & DR ROBERT PETCAVICH
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