Liposome composition for improved intracellular delivery of a therapeutic agent

a technology of liposomes and compositions, applied in the direction of pharmaceutical delivery mechanisms, antibody ingredients, medical ingredients, etc., can solve the problems of the loss of the desired rapid destabilization of the liposome bilayer, and the accompanying rapid release of the entrapped agent into the cell. achieve the effect of increasing the accumulation of therapeutic agents and increasing the accumulation of agents
US20060240009A1Inactive Publication Date: 2006-10-26ZALIPSKY SAMUEL +2
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ZALIPSKY SAMUEL
Publication Date
2006-10-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.
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Description

[0001] This application is a continuation of U.S. application Ser. No. 10 / 108,154, filed Mar. 26, 2002, which claims the benefit of U.S. Provisional Application No. 60 / 278,869, filed Mar. 26, 2001.FIELD OF INVENTION

[0002] The present invention relates to liposomal compositions designed for improved intracellular delivery of an entrapped agent. More specifically, the invention relates to compositions and methods for increasing the intracellular cytotoxicity of a liposome-entrapped agent. BACKGROUND OF THE INVENTION

[0003] Liposomes have long been considered possible vehicles for delivery of therapeutic agents intracellularly. To date, however, success in achieving intracellular delivery of a liposome-entrapped agent has been limited for a variety of reasons. One reason is that liposomes, after systemic administration to the bloodstream, are rapidly removed from circulation by the reticuloendothelial system. Another reason is the inherent difficulty in delivering a molecule, in parti...

Claims

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