Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases

Inactive Publication Date: 2008-05-15
ACTION MEDICINES SL
View PDF3 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0014]The inventors have surprisingly found that 2,5-dihydroxybenzene derivatives, pharmaceutically accepted salts and solvates, as well as isomers and prodrugs thereof are useful for the treatment and/or prophylaxis of hemangiom

Problems solved by technology

Besides surgery which, sometimes is difficult to carry out due to the extent or localization of the tumors, there are no effective treatments approved by health authorities to treat hemangiomas.
Likewise, other vascular tumors such as the hemangioblastoma are difficult to treat.
Current therapies for asthma are partially effective, and it is still one of the main causes of infant mortality.
Even if there are pharmacological treatments for benign prostatic hyperplasia, their efficacy is limited and, in the end, many patients require surgery with at least a partial resection of the gland.
Currently, there are no effective therapies to treat muscle injuries.
Therefore and in spite of the recent scientific advances and of knowledge about the etiology of many diseases described in this invention, there are not really effective treatments for those diseases.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases
  • Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases
  • Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Lotions

[0403]Lotions comprise from about 0.001% to about 30% of the compounds of Formula I, from 1% to 25% of an emollient and the suitable amount of water. Examples of emollients are:[0404]I. Hydrocarbon waxes and oils. Such as mineral oil, petrolatum, paraffin, ceresin, microcrystalline wax, polyethylene and perhydrosqualene.[0405]II. Silicone oils such as dimethyl polysiloxanes, methylphenyl polysiloxanes and water-soluble and alcohol-soluble silicone glycol copolymers.[0406]III. Triglycerides, such as animal and vegetable fats and oils. Examples include, but are not limited to, castor oil, cod liver oil, corn oil, olive oil, almond oil, palm oil, sesame oil, cotton seed oil and soybean oil.[0407]IV. Acetoglyceride esters, such as acetylated monoglycerides.[0408]V. Ethoxylated glycerides, such as ethoxylated glycerol monostearate.[0409]VI. Alkyl esters of fatty acids having 10 to 20 carbon atoms. Methyl, isopropyl and butyl esters of fatty acids are useful herein. ...

example 2

Preparation of Creams

[0430]The compositions of the present invention may be also formulated in the form of a cream. Creams contain from about 0.001% to about 30% of the components of Formula (I), (I′) or (I′″), from 5% to 50% of an emollient and the adequate amount of water. The emollients described above in example 1 are also suitable for the cream formulation. Optionally, the cream may contain an emulsifier at a level from 3% to 50%. The emulsifiers described above in example 1 would also be suitable in this case.

example 3

Preparation of Solutions

[0431]The compositions of the present invention may also be formulated in the form of a solution. Solutions contain from about 0.001% to about 30% of the compounds of Formula (I), (I′) or (I′″) and the adequate amount of an organic solvent. Organic substances useful as the solvent or a part of the solvent system are as follows: propylene glycol, polyethylene glycol (200-600), polypropylene glycol (425-2025), glycerine, sorbitol esters, 1,2,6-hexanetriol, ethanol, isopropanol, diethyl tartrate, butanediol, and mixtures thereof. Such solvent systems can also contain water.

[0432]These compositions are applied on the skin in the form of a solution, or solutions are formulated in the form of aerosol and applied on the skin as a spray. Compositions in the form of aerosol additionally contain from 25% to 80% of a suitable propellant. Examples of propellants include, but are not limited to: chlorinated, fluorinated and fluorochlorinated low molecular weight hydrocarb...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to View More

Abstract

The present invention relates to the use of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and / or prophylaxis of any of the diseases selected from the group consisting of benign prostatic hyperplasia, Barrett's disease, asthma, skeletal muscle and tendon repair, Crohn's disease, ulcerative colitis and leishmaniasis.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of priority under 35 U.S.C. § 119 of ES Application No. P200602217, filed Aug. 16, 2006 and of ES Application No. P200701855, filed Jul. 2, 2007. The foregoing applications, and all documents cited therein, are hereby incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The invention relates to the use of 2,5 dihydroxybenzene compounds and derivatives thereof, its pharmaceutically acceptable salts and solvates, as well as the isomers and prodrugs thereof for the treatment of certain diseases, specifically, for the treatment of hemangiomas, hemangioblastomas, benign prostatic hyperplasia, Barrett's disease, asthma, skeletal muscle and tendon repair, Crohn's disease, ulcerative colitis (proctitis, proctosigmoiditis, pancolitis), leishmaniasis, pain and arthritis; through the administration of a compound including at least one 2,5-dihydroxybenzene compound or a pharmaceutically acceptable salt there...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/22A61K31/225A61K31/185
CPCA61K31/10A61K31/618A61K31/60A61K31/192A61P1/00A61P11/00A61P11/06A61P13/00A61P13/08A61P13/12A61P15/00A61P17/00A61P17/06A61P19/02A61P21/00A61P27/00A61P27/02A61P29/00A61P31/04A61P31/10A61P33/00A61P35/00A61P43/00Y02A50/30
InventorSANCHEZ, PEDRO CUEVASGIMENEZ GALLEGO, GUILLERMOSAENZ DE TEJADA GORMAN, INIGOFRUTOS, JAVIER ANGULORIVAS LOPEZ, LUIS IGNACIOMORENO NUNCIO, FRANCISCO JAVIERFERNANDEZ JAEN, TOMAS FERNADOLOZANO PUERTO, ROSA MARIAROMERO GARRIDO, ANTONIOLOPEZ, SERAFIN VALVERDE
OwnerACTION MEDICINES SL