Crosslinkable polysaccharide derivative, process for producing the same, crosslinkable polysaccharide composition, and medical treatment material
a crosslinkable polysaccharide and polysaccharide technology, applied in the direction of drug compositions, biocides, extracellular fluid disorders, etc., can solve the problems of fibrin glue being difficult to cure, and affecting the cured product. , to achieve the effect of convenient preparation
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example 1
Preparation of Active Esterified Pectin
[0173]In 200 g of DMS was added 2.0 g of acid-type pectin (containing 1.40 mmol / g of carboxy group) prepared in (I)-(1), and dissolved by stirring at 25° C. for 15 hours. The resulted solution was added 0.322 g (2.80 mmol) of NHS and 0.536 g (2.80 mmol) of EDC, followed by stirring at 25° C. for 24 hours. The reaction solution was dropped into 2 L of anhydrous acetone (from Wako Pure Chemical Industries, Ltd.), and a precipitate was recovered by filtration through a suction funnel. The precipitate was washed with 1 L of anhydrous acetone, followed by vacuum drying. Thus the active esterified pectin was obtained. Incidentally, the ratios of Z / X and Y / X were as follows:
[0174]Z / X=1.0 and Y / X=1.0
example 2
Preparation of Active Esterified Hyaluronic Acid
[0175]In 200 g of DMS was added 2.0 g of acid-type hyaluronic acid (containing 2.15 mmol / g of carboxy group) prepared in (I)-(2), and dissolved by stirring at 25° C. for 15 hours. The resulting solution was added 0.575 g (5.0 mmol) of NHS and 0.958 g (5.0 mmol) of EDC, followed by stirring at 25° C. for 24 hours. The reaction solution was dropped into 2 L of diethyl ether (from Wako Pure Chemical Industries, Ltd.), and precipitate was recovered by filtration through a suction funnel. The precipitate was washed with 1 L of tetrahydrofuran (from Wako Pure Chemical Industries, Ltd.), followed by vacuum drying. Thus the active esterified hyaluronic acid was obtained. Incidentally, the ratios of Z / X and Y / X were as follows:
[0176]Z / X=1.0 and Y / X=1.0
example 3
Preparation of Active Esterified CM Dextran A1
[0177]In 200 g of DMS was added 2.0 g of acid-type dextran A (containing 1.01 mmol / g of carboxymethyl group) prepared in (I)-(3), and dissolved by stirring at 100° C. for 15 hours. The resulting solution was added 2.325 g (20.2 mmol) of NHS and 1.162 g (6.06 mmol) of EDC, followed by stirring at 25° C. for 24 hours. The reaction solution was dropped into 2 L of anhydrous acetone, and precipitate was recovered by filtration through a suction funnel. The precipitate was washed with 1 L of anhydrous acetone, followed by vacuum drying. Thus the active esterified CM dextran A1 was obtained. Incidentally, the ratios of Z / X and Y / X were as follows:
[0178]Z / X=3.0 and Y / X=10
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