Recombinant influenza virus-like particles (VLPS) produced in transgenic plants expressing hemagglutinin

a technology of hemagglutinin and vlps, which is applied in the direction of viruses, plant/algae/fungi/lichens ingredients, peptide/protein ingredients, etc., can solve the problems of increasing the risk of emergence or the transmission to humans of a subtype endemic in animals, and the risk of a new subtype or a new subtype is always present, so as to facilitate the capture of glycoprotein anti
US20100310604A1Inactive Publication Date: 2010-12-09MEDICAGO INC
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Patent Information

Authority / Receiving Office
US ¡ United States
Patent Type
Applications(United States)
Current Assignee / Owner
MEDICAGO INC
Publication Date
2010-12-09
Estimated Expiration
Not applicable ¡ inactive patent

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Abstract

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
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Description

[0001] This application is a Continuation-in-Part of and claims priority from PCT Application No. PCT / CA2008 / 001281, filed Jul. 11, 2008. This application also claims priority from Canadian Application No. 2,615,372 filed Jan. 21, 2008; and U.S. Application No. 61 / 022,775 filed Jan. 22, 2008.FIELD OF INVENTION

[0002] The present invention relates to the production of virus-like particles. More specifically, the present invention is directed to the production of virus-like particles comprising influenza antigens.BACKGROUND OF THE INVENTION

[0003] Influenza is the leading cause of death in humans due to a respiratory virus. Common symptoms include fever, sore throat, shortness of breath, and muscle soreness, among others. During flu season, influenza viruses infect 10-20% of the population worldwide, leading to 250-500,000 deaths annually

[0004] Influenza viruses are enveloped viruses that bud from the plasma membrane of infected mammalian and avian cells. They are classified into types A, B...

Claims

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