Krill oil and carotenoid composition, associated method and delivery system

Abstract

A medicine delivery system includes an inner capsule containing carotenoids and an outer capsule in which the inner capsule is contained within the outer capsule and the outer capsule containing a therapeutically effective amount of krill oil. In one example, the carotenoids comprise at least S, S′-astaxanthin derived from Haematococcus pluvialis, and one or more of lutein and/or trans-zeaxanthin or meso-zeaxanthin. The medicine delivery system also includes 0.5 to 8 mg of astaxanthin, 2 to 15 mg of lutein and 0.2 to 12 mg of trans-zeaxanthin contained within the inner capsule. In a specific example, the medicine delivery system includes about 4 mg of astaxanthin, about 10 mg of lutein and about 1.2 mg of trans-zeaxanthin contained within the inner capsule.

Description

RELATED APPLICATION(S)[0001]This application is a continuation-in-part of U.S. patent application Ser. No. 12 / 840,396 filed Jul. 21, 2010, which is based on provisional patent application Ser. No. 61 / 227,881, filed Jul. 23, 2009.FIELD OF THE INVENTION[0002]The present invention relates to a krill oil and carotenoid composition used for eye care or other medical applications and medicine delivery system for the composition. The present invention also relates to a method of preventing, retarding and ameliorating central nervous system and eye diseases, including treating eye insult resulting from disease or injury, such as age-related macular degeneration, photic injury, photoreceptor cell or ganglion cell damage, ischemic insult-related diseases, cataracts, dry eye syndromes and inflammatory diseases.BACKGROUND OF THE INVENTION[0003]The eye is an extension of the brain, and therefore a part of the central nervous system. Accordingly, in the case of an eye injury or disease, i.e., a r...

AI Technical Summary

Benefits of technology

[0051]A medicine delivery system includes an inner capsule containing carotenoids and an outer capsule in which the inner capsule is contained within the outer capsule and the outer capsule containing a therapeutically effective amount of krill oil. In one example, the carotenoids comprise at least S, S′-astaxanthin derived from Haematococcus pluvialis, and one or more of lutein and/

Problems solved by technology

Accordingly, in the case of an eye injury or disease, i.e., a retinal injury or disease, the diseases are often without treatment and the eye cannot be transplanted.

It has been hypothesized that a major cause of these untreatable retinal and other eye diseases and injuries is the generation and presence of singlet oxygen and other free radical species.

Therefore, some untreatable diseases and injuries to the eye result from the continuous exposure of the eye to light, coupled with the highly-oxygenated environment in the eye.

Excessive light energy reaching the retina can cause damage to these neurons, either directly or indirectly, by overwhelming the metabolic systems of these cells.

These free radical species can lead to functional impairment of the cell membranes and cause temporary or permanent damage to retinal tissue.

In addition, a deficiency in removing these reactive free radical species can also contribute to various diseases of the eye.

However, after cataract extraction or other surgical intervention, some of these protective barriers are removed or disturbed, whereby the photoreceptor cells are more susceptible to damage by radiant energy.

Even though several protective mechanisms are present in the eye, a leading cause of blindness in the United States is age-related photoreceptor degeneration.

Unlike cataracts which can be restored by replacing the diseased lens, age-related macular degeneration cannot be treated by replac

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