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Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation

Inactive Publication Date: 2016-11-10
TOCOL PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes methods and compositions for preparing and using a natural substance called tocopherol. The purified tocopherol is safe and effective in preventing oxidative damage and promoting cell health. The pharmaceutical compositions contain a specific amount of tocopherol and can be used to treat various conditions such as radiation exposure and cancer. The compositions can also be used to protect cells from oxidative damage and radiation exposure. The technical effects of the patent are a safer and effective natural substance for protecting cells from oxidative damage and promoting cell health.

Problems solved by technology

It is very difficult to separate the pure tocotrienols from these mixtures and therefore these compounds are very expensive.

Method used

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  • Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
  • Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
  • Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation

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Materials and Methods

Cell Culture

[0036]H9c2 rat cardiomyoctes and immortalized human skin keratinocyte cell line (HaCaT) were kindly donated by Dr. Marsh (UAMS) and Dr. Domann (UIOWA) respectively. Primary human dermal fibroblasts were purchased from LifeLine Cell Technologiees (Frederick, Md.) and rat liver microsomes were purchased from BD Biosciences. All cell lines were grown in Dubelco's Minimal Essential Medium containing high glucose and supplemented with 1 mM sodium pyruvate (Gibco), 10% FBS (Hyclone), and 1% L-glutamine (Gibco) in the presence of 1% penicillin and streptomycin. Cells were maintained and experiments were accomplished in a humidified incubator at 37° C. with 5% CO2. For mitochondrial respiration studies, culture media in cells were changed to unbuffered DMEM supplemented with 4 mM Glutamate and incubated in a non-CO2 incubator for 1 h at 37° C., before they were placed in XF96 Extracellular Flux Analyzer. In all experiments, where DMSO used as vehicle, its fi...

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Abstract

Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and / or other forms of oxidative stress.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This patent application claims the benefit of priority of U.S. Provisional Patent Application No. 62 / 157,383, filed May 5, 2015, which is incorporated herein by reference in its entirety.INTRODUCTION[0002]Vitamin E is composed of eight naturally occurring tocols. Four are tocopherols, which possess a saturated hydrocarbon tail, and four are tocotrienols, which possess three trans double bonds in the hydrocarbon tail. The tocols are known to have beneficial health effects when provided as a dietary supplement. The tocotrienols have recently been shown to have beneficial health effects not seen with the tocopherols.[0003]Commercially available tocotrienols are purified from natural oils, where they occur as complex mixtures of tocotrienols and tocopherols. It is very difficult to separate the pure tocotrienols from these mixtures and therefore these compounds are very expensive.[0004]This invention relates to the preparation of a compositio...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K47/20A61K31/353
CPCA61K47/20A61K31/353A61K31/01A61K36/899A61K45/06A61K2300/00
Inventor COMPADRE, CESAR M.BREEN, PHILIPAYKIN-BURNS, NUKHETHAUER-JENSEN, MARTIN
Owner TOCOL PHARMA LLC