Diabetes Control Using Postprandial Feedback

Abstract

Disclosed is a postprandial glucose-measuring device for preventing the development of or reversing T2D. Included are methods for using the device as well as better use for invasive and noninvasive glucose meters. Further disclosed are novel exercise-sensitizing compositions useful for managing blood glucose levels in Type-2 diabetics with minimal risk of hypoglycemia. The disclosed glucose meters allow a user to also measure exercise and meal size—all with relatively instant feedback—more effectively than having to track the complexity posed by labels, glycemic index and calories. Also disclosed is integration of glucose-measuring devices with smartphones and health monitoring technology to make possible safe and effective interpretation of postprandial glucose readings by a patient to control or reverse Type-2 diabetes.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims benefit of U.S. Provisional Application No. 62 / 071,044, filed Sep. 11, 2014, the U.S. Provisional Application No. 62 / 177,905, filed Mar. 26, 2015, and U.S. Provisional Application No. 62 / 183,267, filed Jun. 23, 2015, and the U.S. patent application Ser. No. 14 / 852,455 filed on Sep. 11, 2015 the contents of which are hereby incorporated by reference.BACKGROUND[0002]Type-2 diabetes (“T2D”) is one of the most common chronic diseases afflicting humans. The hallmark of T2D is abnormally elevated blood glucose levels. Further, dyslipidemia is encountered in many T2D patients. Dyslipidemia typically manifests itself as elevated Low Density Lipoprotein (LDL), depressed High Density Lipoprotein HDL levels and elevated triglyceride levels. About 79 million Americans ages had prediabetes, a predisposition to develop diabetes, about 1.9 million cases of Americans ages were newly diagnosed with T2D adding to the 25.6 million, o...

AI Technical Summary

Benefits of technology

[0011]We have discovered that many fat or fatty acid absorption inhibiting compositions and compounds have an entirely unexpected benefit. They facilitate the use of postprandial exercise as a tool to regulate blood/plasma glucose levels and to even reverse Type-2 Diabetes and make possible the design and use of an entirely different instrument that integrates diet, exercise and glycemic control. These substances have not been reported to synergize with exercise, despite their use for r

Problems solved by technology

In addition sustained abnormally high glucose levels are associated with the risk of strokes, blindness, thickening of the skin, dry skin, infections, and the like.

But in the short term, too low a blood glucose level, termed hypoglycemia, is life threatening.

As a result, in treating diabetes if blood glucose levels are controlled using Traditional Medications to be very close to the normal levels, the risk of hypoglycemia and of PPHG spikes increases as does overall mortality.

Therefore, physicians err on the side of allowing hyperglycemia rather than hypoglycemia when prescribing medications.

Unsurprisingly, sustained hyperglycemia makes T2D a progressive disease that is effectively impossible to reverse by medications alone.

It is known that increased body weight and obesity are risk factors for developing T2D.

While targeting obesity may be sufficient for treating T2D, we realized that it is not a necessary condition or even a useful target in and of itself.

Hypoglycemia is the major risk facing T2D patients using medications to control their plasma glucose levels.

Most of the medications for treating T2D—including the standard of care treatment of initiating treatment with metformin (a biguanide)—carry a significant risk of facilitating hypoglycemia.

An increase in glucose usage can result in hypoglyc

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