Icariside compound, preparation method thereof, and application thereof

Abstract

An icariside compound as shown in Formula I wherein the compound is a natural chemical component in the traditional Chinese herbal epimedium or a chemically modified or a totally synthetic product based on the natural component. The compound can be used for preparing pharmaceuticals, health care products, cosmetic and skin care products and the like for improvement of immunity in a human body.

Description

REFERENCE TO RELATED APPLICATION[0001]This application claims the priority of Chinese patent application No. 201510264195.5 “ICARISIDe COMPOUND, PREPARATION METHOD THEREOF, AND APPLICATION THEREOF” filed on May 20, 2015, hereby incorporated by reference in its entirety.BACKGROUND[0002]Human immunity refers to the ability of the body to protect against causative factors outside or within host cells from infection or invasion, i.e. the ability of the body to maintain a normal and stable environment within the body. In the environments where people live, air, water, food, and most items we contact in daily life, for example, contains a variety of harmful microorganisms such as bacteria, viruses, mycoplasma, chlamydia, fungi and other pathogens (causative factors outside a host cell). Human body may also be affected by the environmental changes, the emergence of a latent virus or bacteria in the host cell, or infection or invasion of cancer cells produced by gene mutation and the like (...

AI Technical Summary

Benefits of technology

The inventors discovered two compounds, icariside I and icariside C, in epimedium that can promote human cells to produce the important immune protein interferon-γ (IFN-γ). This suggests that these compounds may have important applications in improving human immunity. These compounds were tested in various tests and shown to be safe for use with low toxicity and side effects. This patent shows that ikariside compounds can be used for the prevention and treatment of infective diseases and tumor progression and metastasis. It also shows the potential to develop a new pharmaceutical for cellular immune therapy.

Problems solved by technology

When the immunity (antibodies or cytokines etc.) produced by human immune system is not sufficient to fight against the disease causative factors, people get sick.

However, these are specific for certain diseases which greatly limit their applications.

In addition, they are easy to be degraded which have a short half-life and poor bioavailability and which are difficult to be large-scale synthesized, separated and purified.

So far, attempts to find small molecular compounds with good effects on enhancing immunity are not yet successful.

However, systematic studies on the separation of active components therein are rare, in particular that on icariside I and icariside C due to their extremely low content (while its homologue, icariin, has higher content) leading to difficulty in conducting an effective research, let alone industrial application.

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