Sunscreen composition

a sunscreen and composition technology, applied in the direction of pharmaceutical active ingredients, toilet preparations, pharmaceutical delivery mechanisms, etc., can solve the problems of uv-a ray damage or harm to the skin, actinic keratoses and carcinomas, skin disorders, etc., to achieve efficient sunscreen composition, spf, pfa, and critical wavelength

Inactive Publication Date: 2006-03-21
WELLS FARGO BANK NATONAL ASSOC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020]It is an object of the present invention to provide an efficient photoprotective composition.
[0027]These and other objects of the present invention are achieved by a composition comprising one or more photoactive compounds and one or more optimization agents. Surprisingly, the composition requires a small amount of optimization agent to efficiently optimize the polarity, critical wavelength, SPF, PFA, Star Rating, photostability, or any combinations thereof, of the composition. Subsequently, an efficient sunscreen composition is achieved.

Problems solved by technology

However, in the process of doing so, the UV-A rays can damage or harm the skin.
Besides the immediate malady of sunburn, excessive sunlight exposure can lead to skin disorders.
For instance, prolonged and constant exposure to the sun may lead to actinic keratoses and carcinomas.
Another long-term effect is premature aging of the skin.
One problem associated with the use of UV filters, and especially those that are rapidly-degrading photoactive compounds, is that they are not photostable and will degrade rapidly and exponentially when exposed to UV radiation.
It is also well known that the above described UV-A filters, particularly the dibenzoylmethane derivatives, can suffer in rapid photochemical degradation, when used alone or when combined with the above-described most commercially used UV-B filters.
Thus, the efficiency of the sunscreen composition (i.e., SPF, PFA, critical wavelength, Star Rating) containing these photoactive compounds is compromised, unless the photodegradation is controlled by improving the photostability of the system in UVA and / or UVB regions.
In addition, polar solvents tend to decrease the energy required to excite a pi-bonding electron, and increase the energy required to excite a non-bonding electron.
It is also known that the use of different solvents in sunscreen formulations may increase or decrease the effectiveness of a sunscreen chemical.

Method used

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Examples

Experimental program
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Effect test

example 2

[0062]The following additional example demonstrates the effectiveness of the present invention in providing a stable and efficient photoprotective composition. A comparison of a composition according to the present invention (Comp. B) having a optimizing agent (in this case pentylene glycol) to one not having an optimization agent (Comp. A) is set forth below. The test methodology used to determine SPF is the same as that described above with respect to Example 1.

[0063]

TABLE 6Sunscreen Compositions With and Without Pentylene GlycolWeight %INCI Adopted NameComp. AComp. BWater62.377360.8773Octyl Methoxycinnamate7.50007.5000Ethylhexyl Salicylate5.00005.0000C12–15 Alkyl Benzoate5.00005.0000Benzophenone-34.10004.1000Isopropyl Myristate4.00004.0000Cocoglycerides3.50003.5000Glycerin2.00002.0000Acrylates / C12–22 Alkylmethylacrylate2.00002.0000CopolymerButyl methoxydibenzoylmethane1.50001.5000Pentylene GlycolNONE1.5000Phenoxyethanol (and) Methylparaben (and)1.00001.0000Butylparaben (and) Ethy...

example 3

[0066]Test compositions were prepared with octocrylene (Positive control), glycols, glycol derivatives, or isopropyl myristate (Negative control) added to the following sunscreen components: AVOBENZONE—3 g; HOMOSALATE—15 g; OCTYL SALICYLATE—5 g, thus imitating the oil phase of a sunscreen formulation (see Table 7):

[0067]

TABLE 7CompositionsDEC,#ADDITIVE:g23 C.PositiveOctocrylene57.89Control 1 2Pentylene Glycol510.53Ethoxydiglycol (Diethylene58.59glycol monoethyl ether)4BG Monopropionate5851,2-Octanediol (Caprylyl Glycol)58.1NegativeIsopropyl Myristate56.15Control 6 71,2-Hexanediol + 1,2-Octanediol57.88Diethylene Glycol Monobutyl57.6Ether91,2-Hexanediol5810 Octocrylene + 1,2-Octanediol2.5 + 2.57.8NegativeNo additives07.03Control 1112 PEG-7 Methyl Ether57.6913 Octocrylene2.57.7914 Octocrylene and PEG-7 Methyl2.5 + 2.58.36Ether15 Octocrylene + 1,2-Octanediol +2.5 + 1.25 + 1.258.39PEG-7 Methyl Ether

[0068]Referring to Table 7 above, the compositions were applied on Vitro-Skin (0.6 mg / cm2)...

example 4

[0078]Referring to Table 2 above, the PFA of MF2822-1 and MF2822-2 compositions was measured by JCIA Method (methods described in co-pending patent application Ser. No. 10 / 779,314, filed Feb. 13, 2004, which is incorporated in its entirety by reference herein). PFA value is an indicator of a sunscreen's protection in UVA region, which is associated with photoaging, as opposed to the UVB region, which is associated with sunburn. PFA is also is related to the degree of photostabilization of UVA sunscreens, such as avobenzone and its derivatives. So a PFA boost to a sunscreen composition will directly correlate with higher UVA efficacy of a sunscreen as well as a higher degree of photostabilization of a UVA sunscreen.

[0079]It has been unexpectedly found that the inclusion of one or more optimization agents in a photoprotective composition according to the present invention results in a PFA boost to the composition, as compared to a composition without one or more optimization agents. A...

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Abstract

There is provided a composition comprising one or more photoactive compounds and one or more optimization agents. Surprisingly, the composition requires a small amount of optimization agent to efficiently optimize the polarity, critical wavelength, SPF, PFA, Star Rating, photostability, or any combinations thereof, of the composition. Subsequently, an efficient sunscreen composition is achieved.

Description

RELATED APPLICATION[0001]This application claims priority to pending U.S. Provisional Patent Application Ser. No. 60 / 474,362 filed on May 29, 2003, which is incorporated in its entirety by reference herein.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates generally to a photoprotective composition. More particularly, the present invention relates to a sunscreen composition having optimized polarity, critical wavelength, SPF PFA, photostability, Star Rating, or any combinations thereof. The present invention also relates generally to a method of optimizing photoprotective compositions.[0004]2. Description of the Prior Art[0005]Sunscreen compositions are applied to the skin to protect the skin from the sun's ultraviolet rays that can lead to erythema, a reddening of the skin also known as sunburn. Sunlight or ultraviolet radiation in the UV-B range has a wavelength of 290 nm to 320 nm and is known to be the primary cause of sunburn. Ultravio...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K8/00A61KA61K8/34A61Q17/04
CPCA61K8/345A61Q17/04A61K2800/52A61K8/35A61K8/40A61K8/34A61K8/37
Inventor DUEVA-KOGANOV, OLGA V.SANOGUEIRA, JAMES P.
Owner WELLS FARGO BANK NATONAL ASSOC
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