Process for producing sugar chains using beta1,3-N-acetylglucosaminyltransferase

a technology of acetylglucosaminyltransferase and sugar chain, which is applied in the field of new polypeptides, can solve the problems of difficult to synthesize a large amount of poly-n-acetylglucosamine sugar chains, no reports to date on the efficient production of recombinant glycoproteins to which poly, and achieve the effect of efficiently culture the transforman
US7279310B2Inactive Publication Date: 2007-10-09HISASHI NARIMATSU +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
HISASHI NARIMATSU
Publication Date
2007-10-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar chain, DNA encoding the polypeptide, a process for producing the polypeptide, an antibody against the polypeptide, and a diagnosis method and a medicament for treatment for inflammation, cancer or tumor metastasis using the DNA or the antibody. The present invention is useful for synthesis of a useful sugar chain and diagnosis and treatment for inflammatory diseases, cancer or tumor metastasis.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a novel polypeptide having a lactosylceramide β1,3-N-acetylglucosaminyltransferase activity and a paragloboside β1,3-N-acetylglucosaminyltransferase activity; an agent for synthesizing a sugar chain, which comprises the polypeptide as an active ingredient; a DNA encoding the polypeptide, an agent for detecting inflammation, cancer or tumor metastasis, which comprises the DNA; a recombinant DNA obtainable by inserting the DNA into a vector; a transformant comprising the recombinant DNA; a process for producing the polypeptide using the transformant; a process for producing a sugar chain or complex carbohydrate using the polypeptide; a process for producing a sugar chain or complex carbohydrate using the transformant; a method for detecting inflammation, cancer or tumor metastasis using an oligonucleotide obtainable from a DNA encoding the polypeptide; an antibody which recognizes the polypeptide; a method for immunohistostaining u...

Claims

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