The invention discloses a flooding damage control method for water-diversion fracture main channels of drill-hole-grouting plugged overburden rock. The method comprises the steps: collecting surface-drilling columnar data of all coal mining areas according to development characteristics of altitude of water-diversion fractured zones of overburden rock mined under specific mining conditions, determining stratum positions of all key strata in the overburden rock by adopting a key stratum position distinguishing method, then, determining development altitude of a water-diversion fractured zone of each area and areas of distribution of communicating strata and water-bearing strata of each area by an overburden rock water-diversion fractured zone altitude prediction method, finally, laying out the range of distribution of the water-diversion fracture main channels in areas of the communicating water-bearing strata of the water-diversion fractured zones. and determining a grouting drilling type and drilling construction parameters according to borehole tunnel positions, coal bed cover depth and ground drill distribution conditions; after drilling construction is completed, pumping slurry to areas of the water-diversion fracture main channels so as to plug water-diversion fracture channels. The flooding damage control method for the water-diversion fracture main channels of the drill-hole-grouting plugged overburden rock, disclosed by the invention, is determined, can adapt to different mining conditions and can provide a guarantee for water resource protection, flooding damage control and the like of coal mining of mining areas, the use method is reliable, and the practicability is high.