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Application of fenugreek total alkali extract in preparing medicine for ulcerative colitis and preparation method of colon targeted preparation

A technology of Sophora japonica and preparation, which is applied in the field of Sophora japonica total alkaloids to achieve the effect of safe use and low toxicity

Inactive Publication Date: 2008-01-09
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sophora total alkaloids have anti-inflammatory effects on animal inflammation induced by various inflammatory agents, among which matrine, oxymatrine, sophocarpine and aloperine have obvious effects on various acute exudative inflammations. Similar effects to hydrocortisone, but no significant effect on cotton ball-induced chronic inflammation in rats

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Example 1 Total Alkaloids of Sophora flavescens colon positioning capsule

[0112] Sophora flavescens total alkali pellets formula:

[0113] Sophora flavescens total alkali 100g

[0114] Pectin 4g

[0115] Calcium chloride 0.4g

[0116] Eudragit E 2g

[0117] HPMC 12g

[0118] Sophora flavescens total alkali coating solution formula:

[0119] Eudragit S 15g

[0120] Eudragit L 10g

[0121] Triethyl citrate 2g

[0122] Talc 1g

[0123] Water 112g

[0124] Coating parameters:

[0125] Coating liquid flow rate 2.5ml / min

[0126] Inlet temperature 40℃

[0127] Spray pressure 1.2kgf / cm 2

[0128] Weigh the total alkali of Sophora serrata and various auxiliary materials, respectively pass through an 80-mesh sieve, dry at 60°C, mix well, add an appropriate amount of 95% ethanol as a binder to prepare drug-containing pellets with a diameter of about 1.0~1.5mm, at 60°C Dry and sieved. Coating under the above conditions, controlling the coating weight gain by 3 to 6%, and filling it...

Embodiment 2

[0129] Example 2 Total Alkaloids of Sophora flavescens Colon Positioning Capsules

[0130] Sophora flavescens total alkali pellets formula:

[0131] Sophora flavescens total alkali 100g

[0132] Pectin 4g

[0133] Calcium chloride 0.4g

[0134] Eudragit E 2g

[0135] HPMC 12g

[0136] Sophora flavescens total alkali coating solution formula:

[0137] Eudragit S 20g

[0138] Eudragit L 5g

[0139] Triethyl citrate 2g

[0140] Talc 1g

[0141] Water 112g

[0142] Coating parameters:

[0143] Coating liquid flow rate 2.5ml / min

[0144] Inlet temperature 40℃

[0145] Spray pressure 1.2kgf / cm 2

[0146] Weigh the total alkali of Sophora serrata and various auxiliary materials, respectively pass through an 80-mesh sieve, dry at 60°C, mix well, add an appropriate amount of 95% ethanol as a binder to prepare drug-containing pellets with a diameter of about 1.0~1.5mm, at 60°C Dry and sieved. Coating under the above conditions, controlling the coating weight gain by 3 to 6%, and filling it...

Embodiment 3

[0147] Example 3 Total Alkaloids of Sophora flavescens Colon Positioning Capsules

[0148] Sophora flavescens total alkali pellets formula:

[0149] Sophora vulgaris total alkali 10g

[0150] Pectin 4g

[0151] Calcium chloride 0.4g

[0152] Eudragit E 2g

[0153] HPMC 12g

[0154] Sophora flavescens total alkali coating solution formula:

[0155] Eudragit S 15g

[0156] Eudragit L 10g

[0157] Triethyl citrate 2g

[0158] Talc 1g

[0159] Water 112g

[0160] Coating parameters:

[0161] Coating liquid flow rate 2.5ml / min

[0162] Inlet temperature 40℃

[0163] Spray pressure 1.2kgf / cm 2

[0164] Weigh the total alkali of Sophora serrata and various auxiliary materials, respectively pass through an 80-mesh sieve, dry at 60°C, mix well, add an appropriate amount of 95% ethanol as a binder to prepare drug-containing pellets with a diameter of about 1.0~1.5mm, at 60°C Dry and sieved. Coating under the above conditions, controlling the coating weight gain by 3 to 6%, and filling it i...

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Abstract

The invention relates to the application of fenugreek total alkali extract in preparing medicine for ulcerative colitis and preparation method of colon targeted preparation, the preparation employs the significant part of a single Chinese medicinal herb, thus facilitating the product stability and quality control. The release of targeting preparation on the colon can decrease the absorption on the digestive tracts.

Description

Technical field [0001] The present invention relates to the use of the total alkali of Sophora sphaerocarpa, in particular to the application of the total alkali of Sophora sphaerocarpa in the pharmaceutical field. [0002] The invention also relates to a sophora flavonoids total alkali targeting preparation for treating ulcerative colitis and a preparation method thereof. Background technique [0003] Ulcerative Colitis (UC), also known as chronic non-specific ulcerative colitis, is a chronic inflammatory disease of the colon whose etiology is not yet clear. The main features of the disease are inflammation of the mucosa and submucosa of the large intestine (rectum and colon). . Clinically, the main symptoms of this disease are diarrhea, abdominal pain, mucus pus and blood in the stool or pus and blood in the stool, and severe local (intestinal itself) and distant (systemic) complications can occur. The disease often recurs and lasts for several months or even decades. A small n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/489A61P1/04
Inventor 邓虹珠
Owner SOUTHERN MEDICAL UNIVERSITY