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A medicine for treating angina pectoris

A technology for coronary heart disease angina pectoris and a drug, which is applied to the preparation of the above-mentioned drugs, the application in the drug, and the field of drugs for the treatment of angina pectoris, can solve the problems of lack of and inability to fundamentally treat coronary heart disease angina pectoris and the like

Inactive Publication Date: 2008-12-10
北京燕京中科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical treatment of coronary heart disease angina pectoris is mainly western medicine, such as vasodilator drugs, calcium antagonists, anti-platelet aggregation and other therapeutic and preventive drugs, but most of them are drugs that relieve temporary symptoms and cannot fundamentally treat coronary heart disease. The role of angina pectoris, and most of the Chinese patent medicines for the treatment of angina pectoris of coronary heart disease are drugs that simply promote blood circulation and remove blood stasis or tonify qi and blood circulation. Especially coronary heart disease and angina pectoris are mostly middle-aged and elderly people. Therefore, drugs for kidney deficiency should be taken into account in the treatment of drugs, and there is a lack of such drugs on the market.

Method used

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  • A medicine for treating angina pectoris
  • A medicine for treating angina pectoris
  • A medicine for treating angina pectoris

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0117] A. Preparation of inclusion complexes: press L 9 (3 4 ) Orthogonal test design scheme (see Tables 8 and 9), weigh 9 parts of β-CD respectively, add appropriate amount of distilled water, heat and dissolve in a water bath, and make 9 saturated aqueous solutions of β-CD with different concentrations, put them in After reaching the respective levels of temperature in Table 8, add 2ml of volatile oil under continuous stirring, continue stirring for a specified time, take it out, refrigerate for 24 hours, filter with suction, and dry (35-40°C) to obtain white powdery inclusions.

[0118] B. Determination of volatile oil in inclusions: Take 9 inclusions, put them in round bottom flasks respectively, add distilled water, and connect to a volatile oil tester. According to the "Chinese Pharmacopoeia" 2000 edition, the operation under the determination of volatile oil in the first appendix, let it stand for 30 minutes, read the volume of volatile oil, and calculate the recovery ...

Embodiment 1

[0172] (the medicine prepared by the present invention is also called Ge Xiandan in the following examples)

[0173] Please combine figure 1 , is a schematic diagram of the preparation process of the present invention.

[0174] Add 8 times the amount of water to 200 g of turmeric, steam distill for 6 hours, extract the volatile oil, filter, and retain the aqueous solution; 1 hour, stirring speed 3000rpm), refrigerate overnight, filter, and dry at low temperature (40°C); mix the filtered dregs and Epimedium 300g, add water and decoct three times, add 12 times of water each time, and decoct for 0.5 hours each time , combined the decoction, filtered, the filtrate was mixed with the above-mentioned aqueous solution after extracting the volatile oil, concentrated to a relative density of 1.05-1.10 (50°C), placed at room temperature, and the supernatant was centrifuged at a high speed (10000rpm), and the clarified liquid was set aside. Add 667g of Radix Astragali, 400g of Salvia M...

Embodiment 2

[0176] Embodiment 2, long-term toxicity test of Gexiandan granules in rats

[0177] The purpose of this example is to observe whether the long-term oral administration of Gexiandan granules in rats produces cumulative and delayed toxic reactions on the body, so as to provide a basis for safe drug use in clinical practice.

[0178] For the safety of clinical medication, according to the relevant regulations on the research of new Chinese medicines, 80 SD rats were used and divided into control group and Gexiandan Granules 10.5g crude drug / kg, 21g crude drug / kg, 42g crude drug / kg dosage groups (clinical dosage) 59g crude drug / day, the three dosage groups are respectively 12.5, 25, and 50 times of the clinical dosage), administered by intragastric administration for three months continuously, and observing the influence of Gexiandan granules on various indexes of animals.

[0179] 1. Test material

[0180] 1-1. Experimental drug: Gexiandan granule, used for the test to extract c...

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Abstract

The invention provides a medicament for treating coronary heart disease and angina pectoris, which is prepared from astragalus root, root of red rooted saliva, kudzu vine root, epimeddium and curcuma longa through ethanol extracting, vapor distillation, beta cyclodextrin dressing, concentrating, drying, disintegrating into fines, charging sweetener and deflocculating agent.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine for treating angina pectoris. [0002] The present invention also relates to the preparation method of the above-mentioned medicine. [0003] The present invention also relates to the application of the above-mentioned medicament in the preparation of medicament for treating angina pectoris of coronary heart disease. Background technique [0004] Coronary heart disease is one of the most common clinical diseases, and it has always been the top three cause of death in China. According to epidemiological surveys, the incidence and fatality rate of coronary heart disease in my country have increased significantly in recent years. Therefore, the research on the prevention and treatment of coronary heart disease has been included in the national key medical science and technology research projects. Coronary heart disease is a serious disease in which coronary arteries develop and form athero...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/53A61K36/481A61K36/48A61K36/296A61K9/16A61P9/10
Inventor 李延明
Owner 北京燕京中科生物技术有限公司
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