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Process for producing kuh-seng total flavone and flavone salt

A technology of total flavonoids of Sophora flavescens and Sophora flavescens, which is applied in the fields of anti-toxic agents, anti-tumor drugs, organic chemistry, etc., and achieves the effect of simple process, low raw material cost and strong anti-microbial activity

Inactive Publication Date: 2009-08-19
SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Flavonoid salt products have the biological activity of flavonoids, relatively stable chemical properties, can be compatible with alkaline drugs, and are easy to store. There are no reports about their products or production processes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] [1] Add 100g of Sophora flavescens powder of 10-40 meshes to 600ml of aqueous hydrochloric acid solution with pH=3, ultrasonically extract at 10°C for 30 minutes, let stand, filter, and wash the filter residue with the above-mentioned hydrochloric acid solution until there is no alkaloid; filter, and the filtrate can be obtained after treatment. Various flavescens alkaloid products.

[0030] [2] Add 500ml of ethanol to the filter cake obtained by filtering in (1) for ultrasonic extraction at room temperature, filter for 30 minutes, repeat the extraction of the filter cake, and filter until the extract has no yellow color or is very light in color; combine the extracts, and rotary evaporate under reduced pressure to obtain Yellow powder product, containing 80% (UV) of total flavonoids after testing.

Embodiment 2

[0032] [1] Add 100g of flavescens powder of 40-80 mesh to 500ml of acetic acid aqueous solution with pH=5, soak for 6 hours at 20°C, let it stand, filter, and wash the filter residue with the above-mentioned hydrochloric acid solution until there is no alkaloid; filter, and the filtrate can be obtained after treatment. Various flavescens alkaloid products.

[0033] [2] Add 400ml of methanol to the filter cake obtained in (1) and soak for 6 hours, filter, repeat the extraction of the filter cake, and filter until the extract has no yellow color or the color is very light; combine the extract, evaporate and dry naturally to obtain a yellow powder The product contains 82% (UV) of total flavonoids after testing.

Embodiment 3

[0035] [1] Take 100 g of Sophora flavescens powder of 80-120 mesh, extract by percolating with pH=4 sulfuric acid aqueous solution at 30°C until the extract is free of alkaloids; filter and treat the filtrate to obtain various Sophora flavescens alkaloid products.

[0036] [2] Add 500 ml of ethyl acetate to the filter cake obtained by filtering in (1) and reflux for 2 hours, filter, repeat the extraction of the filter cake, and filter until the extract has no yellow color or is very light in color; combine the extracts, and vacuum freeze-dry to obtain yellow The powder product contains 89% (UV) of total flavonoids after testing.

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Abstract

A method for producing total flavonoids and flavonoid salts of Sophora flavescens is to mix Sophora flavescens with a particle size of 10-120 mesh as raw material and acid water in a weight ratio of 1:5-10, and completely extract the alkaloids of Sophora flavescens at 10-40°C , filtered, the filtrate is used for purification and preparation of Sophora flavescens alkaloids, and the filter residue is drained; the obtained filter residue is mixed with a solvent in a ratio of 1g: 4-12ml, extracted, filtered, and the filtrate is processed to obtain total flavonoids or flavonoid salts of Sophora flavescens. The invention has the advantages of separately extracting Sophora flavescens alkaloids and Sophora flavescens flavonoids, low raw material cost, simple process and suitable for industrial production.

Description

technical field [0001] The invention relates to a method for producing total flavonoids and flavonoid salts of Sophora flavescens. technical background [0002] Flavonoids are a class of natural products that widely exist in nature, and their basic core is 2-phenylchromones, which refer to two benzene rings (A, B rings) with phenolic hydroxyl groups connected to each other through the central three carbon atoms. A series of compounds can be divided into flavonoids, flavonols, dihydroflavones, dihydroflavonols, anthocyanins, chalcones, and dihydrochalcones according to the difference of the central 3-carbon chain. , isoflavones, dihydroisoflavones, etc. Experiments have proved that flavonoids have the following effects on animals and humans: ① anti-oxidation and scavenging free radicals; ② synergistic effect on vitamin C; Damaged by carcinogens, inhibiting tumor cell proliferation and anti-free radicals, it has anti-cancer effects; ④ can chelate with metals, protect the acti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/04C07D311/30C07D311/32C07D311/36C07D311/38C07D311/62A61P39/00A61P39/06A61P35/00
Inventor 侯相林邓天昇刘鹏飞
Owner SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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