Reconstruction of HIV-1 Chinese epidemic strain gag gene and recombination DNA vaccine thereof

A DNA vaccine and gene technology, applied in recombinant DNA technology, plant gene improvement, gene therapy, etc., can solve the problems of long expression time and unsuitable application.
CN100547074CInactive Publication Date: 2009-10-07曾毅
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
曾毅
Publication Date
2009-10-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a modified HIV-1 gag gene and a DNA vaccine constructed on the basis thereof. The modified HIV-1 gag gene can be highly expressed in eukaryotic cells independently of the regulatory protein Rev, and the expression level is increased by about 20 times compared with before modification. The DNA vaccine can effectively stimulate cellular immunity and humoral immunity at the same time, and because the target gene contained therein comes from the area where the vaccine is planned to be applied, it is highly representative and pertinent.
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Description

Field of Invention

[0001] The invention belongs to the fields of bioengineering and AIDS prevention and treatment. Specifically, the present invention relates to the modification of gag gene of HIV-1 Chinese epidemic strain and its recombinant DNA vaccine. Background of the Invention

[0002] HIV, the Human Immunodeficiency Virus (HIV), is a member of the family Retroviridae, the genus Lentiviridae, the group of primate lentiviruses. Acquired immunodeficiency syndrome (AIDS) caused by its infection in humans is the world's largest infectious disease that directly threatens human health. Since the HIV epidemic, it is estimated that more than 60 million people have been infected and more than 20 million people have died from HIV / AIDS. According to WHO statistics, as of December 2004, there were 39.4 million (35.9 to 44.3 million) living HIV-infected persons worldwide, of which 4.9 million were newly infected in 2004 (http: / / www.unaids.org / wad2004 / report.html). In China, t...

Claims

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