Preparation method of nanometer ordered structure biomaterial membranous layer based on super hydro philic/hydro phobic characteristic template

A technology of ordered structure and biomaterials, applied in medical science, prosthesis, etc., to achieve the effect of precise and controllable preparation

Active Publication Date: 2007-07-18
BEIJING NATON TECH GRP CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Electrochemical deposition has obvious advantages in the preparation of organic-inorganic composite bio-coating materials, but it is still impossible to achieve controllable preparation of highly ordered nano-micro composite materials similar to natural bone

Method used

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  • Preparation method of nanometer ordered structure biomaterial membranous layer based on super hydro philic/hydro phobic characteristic template
  • Preparation method of nanometer ordered structure biomaterial membranous layer based on super hydro philic/hydro phobic characteristic template

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Embodiment 1

[0023] Embodiment 1: The base material is a pure titanium plate of 15mm×20mm×2mm. After the surface of the titanium plate is polished with sandpaper, it is ultrasonically cleaned in acetone, ethanol and three times of water for 10 minutes, and after taking it out, it is rinsed with three times of water and air-dried for later use. Under room temperature conditions, the electrochemical anodic oxidation of the substrate is carried out, the electrolyte is 0.5wt% HF, the preparation voltage is 20V, and the time is 20 minutes, that is, a layer of nano-ordered TiO is obtained on the surface of the substrate. 2 Nanotube array film layer. The anodized sample was soaked in 1wt% FSA-13 methanol solution for 1 hour, then dried at 140 °C for 1 hour to obtain superhydrophobic TiO 2 Nanotube array film layer. On superhydrophobic TiO 2 The nanotube array film is covered with a photomask, and after being irradiated with ultraviolet light for 60 minutes, a super-hydrophobic-superhydrophilic...

Embodiment 2

[0025]Embodiment 2: the preparation of the nanotube array film layer with super-repellent-super-hydrophilic pattern is the same as in Example 1, and then in the dehydrated ethanol electrolyte containing 3 g / L concentration of hydroxyapatite nanoparticles, the control voltage is At 30V, at room temperature, cathodic electrophoretic deposition was performed on samples with superphobic-superhydrophilic pattern templates. The deposition time is 15 seconds, and a micropattern of hydroxyapatite nanoparticles can be obtained on the surface of the titanium substrate. See Figures 6, 7 and Table 1 for the results. From Figure 6, it can be clearly seen that the brighter circular superhydrophilic region is covered with a layer of hydroxyapatite nanoparticle film, while in the other superhydrophobic regions, there is little or no hydroxyapatite nanoparticle film layer There, a microarray pattern completely consistent with the superphobic-superhydrophilic template (Figure 1) was formed. F...

Embodiment 3

[0029] Similar to Example 1, the difference is that the base material is titanium alloy (Ti6A14V). Use 0.05 mol / L NaOH to adjust the pH of the electrolyte to 6, and the controlled current density is 0.1 mA / cm 2 , for cathodic electrochemical deposition. The deposition time is 5 minutes, and a nano-ordered calcium phosphate (CaP) film layer micropattern is obtained on the surface of the titanium substrate.

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Abstract

A process for preparing a biologic membrane layer with ordered nanostructure and based on the superhydrophilic/superhydrophobic template includes such steps as electrochemically anodizing on Ti-based material to obtain an ordered TiO2 nanotube array membrane, modifying by FsA-13 to obtain superhydrophobic TiO2 nanotube array membrane, covering with mask, ultraviolet irradiating to obtain a superhydrophiclic pattern, and cathode electrochemical deposition or electrophoretic directional deposition to form a surficial nano-CaP ceramic layer.

Description

technical field [0001] The invention relates to a new method for controllably preparing a structurally ordered nanobiological material (calcium phosphorus compound, CaP) film layer on the surface of a medical metal by using a superphilic / superhydrophobic characteristic template through electrochemical deposition or electrophoretic deposition. Background technique [0002] Natural bone is a highly ordered composite material with nano-micro structure formed by self-assembly of calcium phosphate salt and collagen. It is the goal of people's unremitting efforts to prepare artificial biomaterials with natural bone properties. Traditional bone replacement materials, such as metals, ceramics, and medical polymers, can restore some bone functions. A single medical metal material or bioceramic material always has different shortcomings and deficiencies. For example, the biocompatibility and bioactivity of metal materials are poor, and the mechanical properties of ceramic materials a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42
Inventor 林昌健赖跃坤王卉
Owner BEIJING NATON TECH GRP CO LTD
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