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Extraction and separation method for rhubarb willow leaf flavone component

A technology of willow leaf flavonoids and a separation method, which is applied in the field of extraction and separation of flavonoid components from rhubarb willow leaves, can solve the problems of small separation amount and low separation efficiency, and achieves the effects of good method reproducibility and strong operability

Inactive Publication Date: 2007-08-08
ZHEJIANG SCI-TECH UNIV
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Problems solved by technology

[0004] Scholars at home and abroad have conducted chemical research on the leaves, branches or root bark of dozens of willow trees. The extraction and separation methods used in the chemical composition research include: organic solvent extraction, system solvent extraction, classical column chromatography (such as polyacid Amine column chromatography, silica gel column chromatography, Sephadex column chromatography), high performance liquid chromatography (HPLC), paper chromatography, thin layer chromatography, etc.; these classic extraction and separation methods generally have separation volume Less, low separation efficiency and other disadvantages

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  • Extraction and separation method for rhubarb willow leaf flavone component

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with embodiment, and embodiment will help understand the present invention better, but the present invention is not limited only to following embodiment.

[0024] The extraction and separation process is shown in flow chart 1:

[0025] 1. Sample Extraction

[0026]Dried rhubarb willow leaves (collected in Linjiang area in July) 4.8Kg, crushed into coarse powder (80 mesh sieve), soaked in 20% ethanol for 2 hours, and then extracted by microwave, the extraction temperature is medium-high heat, 8 minutes each time , extracted 3 times in total, combined the extracts after filtration, concentrated under reduced pressure to 1.68g of concentrated extract, and the yield was 35%. After dissolving with 3 times the amount of water, extract 3 times with an equal volume of diethyl ether, combine the water layers (divided into two layers, take the lower layer), discard the diethyl ether layer; 3:4 (v / v)) water-sat...

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Abstract

The invention discloses an extracting separating method of flavone from rheum officinale Cynanchum, which is characterized by the following: affirming extracting condition through alcohol; setting the extracting quantity of ether and water stature butanol; comparing the relationship of flavone structure with silica gel thin-layer chromatography, gluglucosan gel thin-layer chromatography and polyamide thin-layer chromatography; affirming the approximate flavone compound to high-effective chromatographic separating purifying structure.

Description

technical field [0001] The invention belongs to a method for extracting and separating natural products, and mainly relates to a method for extracting and separating flavonoids from rhubarb willow leaves, which uses polyamide combined with high-performance liquid chromatography to extract and separate the flavonoids from rhubarb willow leaves, a unique plant of the genus Salix in Changbai Mountain. Background technique [0002] There are more than 500 species of Salix in the whole world, and there are more than 210 species of Salix in my country alone. Willow has a long history in folk medicine. Li Shizhen recorded in "Compendium of Materia Medica": Willow is the lower grade of this classic, its nature is bitter and cold, and it is non-toxic. [3] . Willow is used as medicine mainly based on the root and fibrous root (willow root), branch (willow branch), bast of root (willow bark), leaf (willow leaf), flower (willow flower) of weeping willow (Salix babylonica L.), And hai...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07A61K36/185A61K127/00
Inventor 许传莲赵钰岚邹文涛许根俊赵辅昆
Owner ZHEJIANG SCI-TECH UNIV
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