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Ligustilide extract and its preparing process and application

A technology of chuanxiongolide and yangchuanxiongolide, which is applied in the field of chuanxiongolide extract and preparation thereof, can solve the problems of low efficiency, high content of unsaturated long-chain fatty acids in volatile oil, and high extraction pressure, and achieves simple technological process, The effect of high product yield and low toxicity

Inactive Publication Date: 2007-08-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, these extraction methods have their own advantages and disadvantages.
Although the steam distillation method is simple to operate and can extract low-volatile phthalide components, the disadvantage is that the phthalide components with high volatility, low volatility and thermal instability are greatly lost.
CO 2 The supercritical extraction method has the advantages of high extract yield, no residual solvent, and well-preserved thermally unstable components, but the disadvantage is that the unsaturated long-chain fatty acid content in the obtained volatile oil is high, and the total phthalide content is difficult to exceed Reaching more than 50% of the total amount, and due to the high extraction pressure, the operating conditions are not easy to control, and the loss of equipment is large
Ligusticolide prepared by conventional percolation extraction combined with petroleum ether-aqueous methanol solvent extraction method only contains Lisantrin A and B and three dimers, but this method has low efficiency, so it is difficult to modern large-scale production, and the polarity is relatively high. Large phthalide components lose more
Although solvent extraction combined with solvent extraction is suitable for industrial production, the total amount of the four main lactones in the extract obtained by this method is only 24% to 30%, so it cannot meet the requirements of new drug development

Method used

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  • Ligustilide extract and its preparing process and application
  • Ligustilide extract and its preparing process and application
  • Ligustilide extract and its preparing process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Remove impurities from the Rhizoma Chuanxiong medicinal material, crush it into coarse powder, take 10 kg of coarse powder, add 100 liters of 75% ethanol, and soak overnight at room temperature. Transfer to an extraction tank, heat to 40°C, extract for 1 hour, filter, add 80 liters of the above-mentioned ethanol to the filter residue, and repeat the above operation. The filtrates from the two extractions were combined, and the ethanol was recovered under reduced pressure at 50° C. to a specific gravity of about 1.0 to obtain an extract with a volume of 3 liters. Transfer the above extract into an extraction tank, add 3 liters of distilled water to the extract, and mix well. Add 16 liters of mixed extraction solvent (ethyl acetate:petroleum ether=5:1), stir under pressure at room temperature for 10 min, let stand for 24 hours, and separate the organic layer. Add 9 liters of mixed extraction solvent (ethyl acetate:petroleum ether=5:1) to the aqueous layer, stir under pres...

Embodiment 2

[0032] Remove impurities from the Rhizoma Chuanxiong medicinal material, crush it into coarse powder, take 10.2 kg of coarse powder, add 100 liters of 80% ethanol, and soak overnight at room temperature. Transfer to an extraction tank, heat to 40°C, extract for 1 hour, filter, add 80 liters of the above-mentioned ethanol to the filter residue, and repeat the above operation. The filtrates from the two extractions were combined, and the ethanol was recovered under reduced pressure at 50° C. to a specific gravity of about 1.0 to obtain an extract with a volume of 3.1 liters. Transfer the above extract into an extraction tank, add 2 liters of distilled water to the extract, and mix well. Add 10 liters of mixed extraction solvent (ethyl acetate:petroleum ether=8:1), stir under pressure at room temperature for 20 min, let stand for 48 hours, and separate the organic layer. Add 8 liters of mixed extraction solvent (ethyl acetate:petroleum ether=1:1) to the aqueous layer, stir under...

Embodiment 3

[0034] Remove impurities from the Rhizoma Chuanxiong medicinal material, crush it into coarse powder, take 9.6 kg of coarse powder, add 100 liters of 70% ethanol, and soak overnight at room temperature. Transfer to an extraction tank, heat to 40°C, extract for 1 hour, filter, add 80 liters of the above-mentioned ethanol to the filter residue, and repeat the above operation. The filtrates from the two extractions were combined, and the ethanol was recovered under reduced pressure at 50° C. to a specific gravity of about 1.0 to obtain an extract with a volume of 2.5 liters. Transfer the above extract into an extraction tank, add 2 liters of distilled water to the extract, and mix well. Add 12 liters of mixed extraction solvent (ethyl acetate:petroleum ether=7:1), stir under pressure at room temperature for 30 min, let stand for 24 hours, and separate the organic layer. Add 8 liters of mixed extraction solvent (ethyl acetate:petroleum ether=7:1) to the aqueous layer, stir under ...

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Abstract

The invention discloses a preparation method and application of extract of cnidium lactone. The extract of cnidium lactone is extracted from medicinal materials or decoction pieces of chuanxiong rhizome, Cnidium offcinale Makino, Angelica, or Acutelobed angelica, wherein the content of cnidium lactone occupies over 50% of the total weight of extract, total content of ligustilide, Senkyunolide A, Senkyunolide H, and Senkyunolide I occupy over 30% of the total weight of extract. Total lactone content in the cnidium lactone extract is over 30%, total content of lactone in four active constituents is over 30%, thus the product has high purity and no residual solvent. in addition, the preparation method of the invention has the advantages of low toxicity solvent, simple process, high yield, and low cost, thus is suitable for modernize industrial production.

Description

technical field [0001] The invention relates to an extract of plant-like Chinese medicinal materials or Chinese medicinal pieces and its preparation method and application, in particular to a chuanxiong lactone extract and its preparation method and application. Background technique [0002] Chuanxiong (Ligusticum chuanxiong Hort.) is a plant of the genus Ligusticum in the Umbelliferae family. The medicinal part is the rhizome. Since 1977, the Beijing Institute of Pharmaceutical Research published an article titled "Research on the Active Components of Ligusticum Chuanxiong" in the 7th issue of "Chinese Medical Journal" and named tetramethylpyrazine as "Ligustrazine (TMP)". Expand quickly. Ligustrazine can pass through the blood-brain barrier, has the effects of anti-platelet aggregation, dilating blood vessels, etc., which is very similar to the pharmacological effects of Ligustra, so it is generally believed that Ligustrazine is the main effective chemical component of Li...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K36/236A61P9/10A61P25/06A61P29/00C07D307/88
Inventor 杨学东孙广平丁明玉
Owner TIANJIN UNIV
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