Determination method for entrapment efficiency of liposome

A measurement method and liposome technology, applied in the direction of testing pharmaceutical preparations, special data processing applications, instruments, etc., can solve the problems of long time consumption, large error in results, and high requirements for instruments, and achieve short time consumption, good accuracy, and experimental results. low cost effect
CN101017164AInactive Publication Date: 2007-08-15SHANGHAI UNIV OF T C M
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI UNIV OF T C M
Publication Date
2007-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention discloses one test method with drug fat package rate, which comprises the following steps: adding the liquid not reacting with resin double molecule layer into resin mixture hanging liquid to achieve balance through dialysis water concentration to get outer phase for fat test; this invention adds double molecule layer without reaction into sample to be tested; filtering to get property liquid to test its medicine and liquid concentration to compute discrete bus to pack rate.
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Description

technical field

[0001] The invention relates to a method for measuring the drug encapsulation efficiency of a drug-containing liposome. Background technique

[0002] Liposomes are closed vesicles with a bilayer structure made of phospholipids and (or without) additives as the skeleton membrane material. There are two long hydrophobic hydrocarbon chains and a hydrophilic group in the common phospholipid molecular structure. When an appropriate amount of phospholipid is added to water or buffer solution, the phospholipid molecules are aligned, and the hydrophilic groups face the water phase on both sides. , The hydrophobic hydrocarbon chains are relatively associated with each other and form a bilayer to form a liposome. The phospholipids used to prepare liposomes include natural phospholipids, such as soybean phospholipids, egg yolk phospholipids, etc.; synthetic phospholipids, such as dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, etc. A commonly used addit...

Claims

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