Metal complex using plumbagin as ligand, synthesizing method and usage thereof

Abstract

The invention discloses a metal chelate which takes plumbagin as ligand, and the synthesis method and application thereof. The metal chelate is represented by the right formula, wherein, M represents the metal ion able to accept lone pair electrons can be main group matel ion, or transition metal ion, or rare earth metal ion such as Ca(II), Mg(II), Sn(IV), Cu(II), Co(II), Ni(II), Zn(II), Fe(II), Mn(II), Ag(I), Mo(VI), Pd(II), Ru(III), W(VI), Pt(II), Y(III), La(III), Nd(III), Sm(III), Eu(III), Er(III). The invention synthesizes a series of metal chelate which takes plumbagin as ligand and reacts with the metal salt. The produced chelate has an inhibition to a plurality of tumor line. The result indicates a plurality of chelate having a more remarkable anti-tumor activity than the plumbagin and have a higher medicine value and can be used for the preparation of different anti-tumor medicine.

Description

(1) Technical field:

[0001] The invention relates to a metal coordination compound, especially a metal complex with plumbagin as a ligand; the invention also relates to a synthesis method and application of the metal complex. (two) background technology:

[0002] Plumbagin (Plumbagin) is a natural bioactive molecule isolated from Plumbagozeylanica (Plumbagozeylanica), also known as Plumbagin, and its chemical name is 5-hydroxy-2-methyl-1,4- Naphthoquinone has antibacterial, anti-inflammatory and antitumor effects. Anti-tumor in vitro experiments show that plumbagin has strong cytotoxic activity, such as can significantly inhibit leukemia cells (Raji), lung cancer cells (Calu-1), uterine cancer cells (HeLa) and epithelial cells (Wish), etc. growth of tumor cells, IC 50 The values ​​are 8.1 μM, 25.0 μM, 21.5 μM and 21.2 μM, respectively. (See literature: Nguyen A T, Malonne H Duez P. Cytotoxic constituents from Plumbago zeylanica. Fitoterapia, 2004, 75: 500-504); in vivo ex...

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