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Method for producing compound frame of injection type polyester micro-carrier and fibrin gel

A fibrin gel and composite scaffold technology is applied in the field of preparation of injectable polyester microcarriers and fibrin gel composite scaffolds, and can solve the problem that the cell growth space cannot be maintained, the hydrogel mechanical strength is low, broken or damaged. Collapse and other problems, to achieve good application prospects, good biocompatibility and degradation performance, and the effect of promoting migration

Inactive Publication Date: 2007-09-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical strength of hydrogel is low, and the degradation rate is fast, resulting in broken or collapsed, thus losing its proper shape and unable to continue to maintain the growth space of cells

Method used

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  • Method for producing compound frame of injection type polyester micro-carrier and fibrin gel
  • Method for producing compound frame of injection type polyester micro-carrier and fibrin gel
  • Method for producing compound frame of injection type polyester micro-carrier and fibrin gel

Examples

Experimental program
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Effect test

example 1

[0029] 1) Polylactic acid-glycolic acid copolymer is dissolved in methylene chloride, is mixed with the homogeneous solution that concentration is 50mg / ml; This solution is joined in the polyvinyl alcohol solution that mass concentration is 0.1%, the aqueous solution of polyvinyl alcohol The volume ratio of dichloromethane and dichloromethane is 5:1. Volatilize under mechanical stirring for 8 hours to remove dichloromethane; filter and separate polylactic acid-glycolic acid copolymer microspheres, and dry;

[0030] 2) Soak the polylactic acid-glycolic acid copolymer microspheres obtained in step 1) in a hexamethylenediamine n-propanol solution with a mass concentration of 6%, react in a water bath at 40° C. for 3 minutes, and fully wash with deionized water to Unreacted hexamethylenediamine was removed, and then dried to constant weight in a vacuum oven at 35°C to obtain polylactic acid-glycolic acid copolymer microspheres containing amino groups on the surface. Fig. 2 is a s...

example 2

[0035] The same as step 1) of Example 1 to prepare polymer microspheres, but the polymer used is polylactic acid, and the rest of the steps are the same as in Example 1 to obtain a composite scaffold of injection-type polylactic acid microcarriers and fibrin gel.

example 3

[0037] Same as step 1) of Example 1 to prepare polylactic acid-glycolic acid copolymer microspheres, but the mass concentration of polyvinyl alcohol solution is 0.5%, and all the other steps are the same as Example 1.

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PUM

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Abstract

The invention discloses a method for preparing a composite support of injection polyester micro carrier and fibrin gel, wherein the composite support is formed by composed fibrin gel and polyester micro carrier. The micro carrier supply physical strength and space for cell growth and expansion, the fibrin gel simulates the cell epimatrix of cartilage cell, to support the transmission and original injection shaping of micro carrier, and accelerate the transfer, increment and differentiation of cartilage cell, and accelerate the healing of cartilage cell. The inventive composite support can effectively load micro carrier from free movement in body and loss in plant process, with better biological compatibility, simple preparation, wide resource, high producing efficiency and wide application.

Description

technical field [0001] The invention relates to a preparation method of an injection-type polyester microcarrier and fibrin gel composite support. Background technique [0002] Cartilage injury is a common disease at present, and the articular cartilage injury caused by arthritis or sports trauma brings pain to many patients. Cartilage has active metabolism and limited repair ability. It has no blood vessels, cannot form fibrous clots after injury, has no migration of inflammatory cells, and no vascular undifferentiated cells into the damaged site, so it is not easy to repair by itself. In addition, cartilage itself lacks undifferentiated cells at the injury site, and no chondrocytes migrate and grow into the injured cartilage after injury. Moreover, with age, the ability of chondrocytes to divide gradually decreases, and the ability to produce extracellular matrix also decreases. So far, clinically, there is still a lack of effective methods to repair damaged cartilage ti...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/22
Inventor 高长有马列赵海光沈家骢
Owner ZHEJIANG UNIV
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