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Method of extracting and separating aralia saponin from aralia mandshrica

A technology of aralia saponin and aralia aralia, which is applied in the field of preparation of aralia saponin, can solve the problems of high impurities in the extract and low yield, and achieve the effect of high content, high yield, and favorable industrial production

Inactive Publication Date: 2007-10-17
宋云飞
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] After patent inquiry, no patent was found on the method of extracting and separating Aralia saponin from Aralia japonica, but it was found that the application number "02801003.5 preparation method of Aralia genus plant extract with increased anti-hepatitis B virus activity and the The drug and food composition of the extract", the invention discloses a method for preparing the organic solvent-soluble extract of the plant of the genus Aragaria, which has improved efficacy in preventing or treating liver diseases. Pulverizing the plant; mixing the pulverized product with water; heating the mixture to obtain an extract solution; removing water-insoluble components from the extract solution to prepare a water-soluble extract
There are many impurities in the extract obtained by this preparation method, the yield is low, and there are many improvements

Method used

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  • Method of extracting and separating aralia saponin from aralia mandshrica

Examples

Experimental program
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Effect test

Embodiment 1

[0016] (1) Raw material processing: first dry the fresh Aralia aralia, the temperature is controlled at 65-75°C or sun-dried, remove impurities, crush, and pass through a 10-40 mesh sieve;

[0017] (2) Extraction and concentration: after crushing the raw materials, use 5 times the amount of 60% ethanol to reflux and extract twice, each time for 2 hours, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and centrifuge to remove the precipitate;

[0018] (3) Column chromatography: take the precipitated supernatant and pass it through the D101 macroporous adsorption resin for adsorption, wash the resin with purified water until it is colorless, and elute with 60% ethanol until the effluent is colorless, collect and combine The eluate is concentrated under reduced pressure, ethanol is recovered, and then purified by neutral alumina resin, eluted with purified water, and the eluate is collected until complete;

[0019] (4) Drying: Concentrate...

Embodiment 2

[0021] (1) Raw material processing: directly pulverize the dried Aralia japonica after removing impurities, and pass through a 10-40 mesh sieve;

[0022] (2) Extraction and concentration: after crushing the raw materials, use 6 times the amount of 65% ethanol to reflux to extract twice, each time for 2 hours, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and centrifuge to remove the precipitate;

[0023] (3) Column chromatography: take the precipitated supernatant and pass it through HP20 macroporous adsorption resin for adsorption, wash the resin with purified water until it is colorless, and elute with 60% ethanol until the effluent is colorless, collect and combine The eluate is concentrated under reduced pressure, ethanol is recovered, and then purified by neutral alumina resin, eluted with purified water, and the eluate is collected until complete;

[0024] (4) Drying: Concentrate the eluent into a thick paste (13-18 pomi), then...

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Abstract

The present invention discloses a method for extracting araloside from Aralia Elata. Aralia Elata is used as material, a powdery, white or white-like araloside is obtained through extraction, concentration, column chromatography, drying. The general content of araloside (A,B,C,D) is more than 90% (HPLC test). The invention employs a simple and mature process by using column chromatography and extracts araloside from Aralia Elata The product has high content of araloside and product yield is high which is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of preparation of plant extracts, in particular to a preparation method for extracting aralia saponin, an active ingredient of medicine, from aralia japonica. Background technique [0002] Aralia eleta (Aralia eleta) is a small deciduous tree belonging to Araliaceae. It is an emerging economic tree in the northeast forest area. Because of its large buds, crisp and delicious, high nutritional value, it has health benefits. Function, thus become the favorite green food in the market. Its leaves, roots, and skin contain a large amount of araloside, which is three times that of ginseng, and has high medical value. Studies have shown that araloside has similar functions to ginsenoside, and has anti-cancer, anti-cancer, and anti-aging effects. In addition, it can reduce the urine microalbumin content of diabetic rats, improve the ultrastructure of the kidney, prevent the thickening of the basement membrane, and p...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K36/25
Inventor 宋云飞
Owner 宋云飞
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