Shapable biodegradable polymer
Through the combination of starch, water-soluble polymers, polyol plasticizers and emulsifiers, the problem of insufficient biodegradability and mechanical properties in injection molded tampon applicators is solved, achieving high-performance, low-cost biodegradable injection Preparation of shaped polymers.
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Problems solved by technology
Method used
Examples
Embodiment 1
[0071] A formulation was developed containing the same levels and relative proportions of starch, PVOH and stearic acid as the "control" formulation, except that it contained 23% plasticizer (by dry weight). The plasticizer system consisted of a mixture of glycerol, maltitol and sorbitol in a ratio of 3.3:1.5:1. Additionally, the formulation contained 1% polyethylene oxide to provide biocompatibility and 1.7% glyceryl monostearate as an emulsifier. As shown in Table 5, this formulation met all the mechanical properties required for a tampon applicator.
Embodiment 2
[0073] The second formulation was the same as Example 1 except for the composition of the plasticizer consisting of glycerol, maltitol and sorbitol in a ratio of 4.3:1:3.5. As shown in Table 4, a significant increase in the content of sorbitol resulted in an increase in Young's modulus.
Embodiment 3
[0075] The control formulation was not suitable for use in the tampon applicator because it failed the cytotoxicity test, which is necessary to ensure biodegradability to the level required for a Class IIA medical device. In this example, stearic acid, which plays a role in cytotoxicity, was removed and 0.6% PEO was added.
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Abstract
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