Coated ubenimex table

A technology of Ubenimex and film-coated tablets, which is applied in the direction of medical preparations of non-active ingredients, organic active ingredients, non-effective ingredients of polymer compounds, etc., and can solve problems such as unconsidered

Active Publication Date: 2007-11-07
深圳万乐药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets are suitable for substances that are easily soluble and have high bioavailability. Since Ubenimex is insoluble, in order to ensure its solubility and dissolution rate, researchers usually do not consider this dosage form in the selection of preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Ubenimex 15g

[0015] Lactose 68.5g

[0016] 70g pregelatinized starch

[0017] Polyvinylpyrrolidone 3g

[0018] Sodium carboxymethyl starch 5g

[0019] Magnesium Stearate 1.5g

[0020] Opadry II 6g

[0021] Pass ubenimex, lactose, microcrystalline cellulose and sodium carboxymethyl starch through a 80-100 mesh sieve, mix well, add polyvinylpyrrolidone solution to make a soft material, use a 18-24 mesh sieve to make wet granules, and dry at low temperature. Sieve with 18-24 mesh for granulation, add sodium carboxymethyl starch and magnesium stearate, mix well, and press into tablets. Alternatively, pass ubenimex, lactose, microcrystalline cellulose and sodium carboxymethyl starch through a 80-100 mesh sieve, mix them uniformly as a base material, and use polyvinylpyrrolidone solution to granulate in a fluidized bed at 25-100°C for 18 ~24 mesh sieve for granulation, add sodium carboxymethyl starch and magnesium stearate, mix evenly, and compress into tablets. The ...

Embodiment 2

[0023] Ubenimex 30g

[0024] Lactose 120g

[0025] Microcrystalline Cellulose 150g

[0026] Croscarmellose Sodium 15g

[0027] Stearic acid 5g

[0028] Opadry II 20g

[0029] Pass ubenimex, lactose, microcrystalline cellulose and sodium carboxymethyl starch through a 80-100 mesh sieve, mix well, dry granulate with a 18-40 mesh sieve, add sodium carboxymethyl starch and magnesium stearate , mix evenly, and press into tablets. The tablet core that makes carries out film coating, and method is the same as embodiment 1.

[0030] In order to investigate the dissolution rate of ubenimex film-coated tablets, the dissolution rate of ubenimex film-coated tablets prepared by implementation 1 and 2 was measured.

[0031] 6 pieces of Ubenimex film-coated tablets were respectively used hydrochloric acid solution (24ml of dilute hydrochloric acid to add water to 1000ml) as the solvent, the rotating speed was 75 rpm, and samples were taken after 30 minutes, and determined by high perfo...

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PUM

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Abstract

The present invention discloses one kind of coated Ubenimex tablet, which consists of Ubenimex 10-30 weight portions, disintegrant 3-20 weight portions, diluent 50-300 weight portions, lubricant 1-5 weight portions and water soluble coating material 2-20 weight portions. Compared with marketable Ubenimex capsule, the coated Ubenimex tablet has the same dissolution and bioavailability, but simple preparation process and low production cost.

Description

technical field [0001] The invention relates to a common tablet of ubenimex, in particular to an ubenimex film-coated tablet. Background technique [0002] As an immunomodulator, Ubenimex has obvious curative effect on acute and chronic myeloid leukemia, lung squamous cell carcinoma, nasopharyngeal carcinoma and other solid tumors. Ubenimex combined with conventional chemotherapy or radiotherapy can significantly prolong the remission period and survival period of the above-mentioned cancer patients, and significantly improve the quality of life of the patients. [0003] Chinese patent applications CN1943562A and CN1706373A respectively disclose a dispersible tablet and an orally disintegrating tablet of Ubenimex. Ubenimex is odorless, bitter in taste, slightly soluble in water, and belongs to poorly soluble drugs. "Pharmacopoeia of the People's Republic of China (2005 Edition II)" mentions that the drug in the dispersible tablet should be insoluble, so Ubenimex can be mad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/32A61K31/198A61K47/10A61K47/36A61K47/38A61K47/34A61K47/40A61P37/02A61P35/00
Inventor 曾嘉铨卓秋琪张汉利宝玉荣左鸿宇
Owner 深圳万乐药业有限公司
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