Povidone-iodine antibacterial material and its production

An antibacterial material, povidone-iodine technology, applied in the field of polymer material synthesis, can solve the problem of unsuitable fixation of carboxymethyl chitosan, and achieve the effect of easy control of process conditions, low cost and good antibacterial effect

Active Publication Date: 2007-11-21
陈煜 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this cross-linked carboxymethyl chitosan is not suitable for immobilization of iodine antibacterial drugs

Method used

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  • Povidone-iodine antibacterial material and its production
  • Povidone-iodine antibacterial material and its production
  • Povidone-iodine antibacterial material and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] After fully dissolving 1.5 parts of carboxymethyl chitosan in distilled water, control the system temperature at 80°C, add acrylate and N-vinylpyrrolidone total mass of 2.5wt% azobisisobutyronitrile under nitrogen protection, and react After 30 minutes, add the unsaturated vinyl monomer mixture that is 10:1 with carboxymethyl chitosan mass ratio, the massfraction of the acrylic acid neutralized with sodium hydroxide in this mixture is 70%, the N-vinylpyrrolidone The mass fraction is 30%, and the cross-linking agent N,N'-methylenebisacrylamide of 2wt% monomer is added at the same time, the total water in the control system and the monomer mass ratio are 15:1, and the reaction is carried out at 80°C for 5 hours After the reaction is stopped, the product is precipitated with ethanol with a mass ratio of 18:1 to the monomer, and then the precipitate is broken up by high-speed stirring at 2500 rpm, and washed with ethanol repeatedly under high-speed stirring, and then the fil...

Embodiment 2

[0037] The reaction process of this embodiment is the same as that of Example 1, but potassium hydroxide is used to neutralize the acrylic acid monomer during the preparation process of carboxymethyl chitosan graft (polyacrylate copolymer-N-vinylpyrrolidone). The available iodine content of the product is 1.12%, the diameter of the maximum inhibition zone against Escherichia coli is 9.1±1.7mm, and the maximum inhibition zone diameter against Staphylococcus aureus is 18.8±2.5mm.

Embodiment 3

[0039] After fully dissolving 1.5 parts of carboxymethyl chitosan in distilled water, control the temperature of the system at 60° C., add azobisisobutyronitrile with a total mass of acrylate and N-vinylpyrrolidone of 2.5 wt % under nitrogen protection, and react After 30 minutes, add the unsaturated vinyl monomer mixture that is 10:1 with carboxymethyl chitosan mass ratio, the massfraction of the acrylic acid neutralized with sodium hydroxide in this mixture is 70%, the N-vinylpyrrolidone The mass fraction is 30%, and the cross-linking agent N,N'-methylenebisacrylamide of 2wt% monomer is added at the same time, the total water in the control system and the monomer mass ratio are 15:1, and the reaction is carried out at 60°C for 8 hours After the reaction is stopped, the product is precipitated with ethanol with a mass ratio of 18:1 to the monomer, and then the precipitate is broken up by high-speed stirring at 2500 rpm, and washed with ethanol repeatedly under high-speed stirr...

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Abstract

The invention is concerned with the preparation method for new povidone iodine anit-bacterium dressing that uses the carboxymethyl chitosan to fix. The graft of the carboxymethyl chitosan (Polyacrylates - copolymer - N - vinylpyrrolidone) dissolves in water and processes complexation with iodine, reduces pressure and distillation to wipe off the solvent and part of un-reactive iodine, uses normal heptanes to marinate and wash the produce in order to wipe off the un-reactive iodine, processes freeze drying and crushing to get the new povidone iodine anit-bacterium dressing that uses the carboxymethyl chitosan to fix: t he graft of the carboxymethyl chitosan (Polyacrylates - copolymer - N - vinylpyrrolidone).

Description

technical field [0001] The invention relates to a novel povidone-iodine antibacterial material and a preparation method thereof. It belongs to the field of synthesis of polymer materials. technical background [0002] Traditional I 2 - Alcohol solution is a commonly used medical disinfectant, which is widely used in the disinfection of surgical wounds and surgical instruments. Traditional clinical disinfection is to use iodine, but because the alcohol in iodine has irritation and side effects on the human body, it is difficult to adapt to many treatment processes. I 2 As a bactericidal and disinfecting active ingredient, the solubility in water is very small, I 2 The aqueous solution can not achieve the effect of sterilization. Polyvinylpyrrolidone (PVP) is a new type of non-ionic water-soluble polymer material. It has excellent complexation properties and can be complexed with iodine molecules to form an efficient, broad-spectrum, non-toxic antibacterial agent povidone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N55/00C08B37/08A61L2/00A01P1/00
Inventor 谭惠民陈煜
Owner 陈煜
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