Polylysine for support frame coating

A polylysine and coating technology, applied in the field of stents, can solve the problems of short effective time and low drug release rate, and achieve the effects of prolonging release time, improving release efficiency, good biocompatibility and degradability

Inactive Publication Date: 2018-03-20
成都测迪森生物科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In bioreduced polymer materials, the drug release rate is low and the effective time is short.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0020] Specific embodiment 1: a kind of polylysine for stent coating, preparation method is as follows:

[0021] Step 1. Insert the bacterial strain into the medium for cultivation, and cultivate it at 25-30° C. for 40 hours. The medium includes: 100 parts by weight of distilled water, 2 parts of glucose, 0.1 part of sodium chloride, 0.1 part of chlorine Calcium chloride: 0.1 part, ammonium chloride: 0.1 part, magnesium chloride: 0.1 part, and the pH value of the culture medium is 6.5.

[0022] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate it at 25-30° C. for 48 hours; the fermentation medium includes: 100 parts by weight of distilled water, 0.2 parts of peptone, yeast 0.2 parts of cream, 0.5 parts of glycerin, and 0.5 parts of glucose, and the pH value of the fermentation medium is 6.5.

[0023] Step 3, centrifuging the above fermented liquid for 20 minutes, collecting the cells, h...

specific Embodiment 2

[0025] Specific embodiment 2: a kind of polylysine for stent coating, preparation method is as follows:

[0026] Step 1. Insert the bacterial strain into the culture medium and culture it at 25°C for 40 hours. The culture medium includes: 100 parts by weight of distilled water, 2 parts of glucose, 0.1 part of sodium chloride, calcium chloride : 0.1 part, ammonium chloride: 0.1 part, magnesium chloride 0.1 part, the pH value of the medium is 6.5.

[0027] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculum amount of 5%, and cultivate it at 25°C for 48 hours; the fermentation medium includes: 100 parts by weight of distilled water, 0.2 parts of peptone, and 0.2 parts of yeast extract part, 0.5 part of glycerol, 0.5 part of glucose, and the pH value of the fermentation medium is 6.5.

[0028] Step 3, centrifuging the above fermented liquid for 20 minutes, collecting the cells, heating in a water bath, taking the supernata...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a polylysine for stent coating, which belongs to the medical field. The preparation method is as follows: step 1, inserting the bacterial strain into a medium for cultivation, and culturing at 25-30°C for 40 hours; step 2, Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate it at 25-30°C for 48 hours; step 3, centrifuge the above-mentioned fermentation solution for 20 minutes, collect the cells, heat them in a water bath, and take the supernatant liquid, and drain the water to obtain polylysine; step 4: dissolve 2-amino-3-p-hydroxyphenylpropionic acid monomer and peroxide initiator in an organic solvent to obtain a solution; secondly and prepare The obtained polylysine powder is mixed, and the mixture is grafted and modified through a melt grafting reaction device to obtain a polylysine grafted 2-amino-3-p-hydroxyphenylpropionic acid biodegradable polymer.

Description

technical field [0001] The present invention relates to the field of stents. Background technique [0002] Cardiac stent (Stent), also known as coronary stent, is a medical device commonly used in cardiac interventional surgery and has the function of dredging arteries. The main materials are stainless steel, nickel-titanium alloy or cobalt-chromium alloy. [0003] Existing metal stents easily lead to restenosis of blood vessels. In a new type of stent, anti-thrombotic and anti-proliferative drugs are wrapped on the heart stent. After the stent is implanted, the drug is released slowly, which can increase the local drug concentration, reduce side effects, and reduce the rate of restenosis. [0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In biodegradable polymer materials, the drug release rate is low and the effective time is short. Contents of the invention [0005] The object of the present invention is: to the abo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C12P13/02C09D177/04
CPCC08G69/48C09D177/04C12P13/02
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap