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Polylysine for support frame coating

A polylysine and coating technology, applied in the field of stents, can solve the problems of short effective time and low drug release rate, and achieve the effects of prolonging release time, improving release efficiency, good biocompatibility and degradability

Inactive Publication Date: 2018-03-20
成都测迪森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In bioreduced polymer materials, the drug release rate is low and the effective time is short.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0020] Specific embodiment 1: a kind of polylysine for stent coating, preparation method is as follows:

[0021] Step 1. Insert the bacterial strain into the medium for cultivation, and cultivate it at 25-30° C. for 40 hours. The medium includes: 100 parts by weight of distilled water, 2 parts of glucose, 0.1 part of sodium chloride, 0.1 part of chlorine Calcium chloride: 0.1 part, ammonium chloride: 0.1 part, magnesium chloride: 0.1 part, and the pH value of the culture medium is 6.5.

[0022] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate it at 25-30° C. for 48 hours; the fermentation medium includes: 100 parts by weight of distilled water, 0.2 parts of peptone, yeast 0.2 parts of cream, 0.5 parts of glycerin, and 0.5 parts of glucose, and the pH value of the fermentation medium is 6.5.

[0023] Step 3, centrifuging the above fermented liquid for 20 minutes, collecting the cells, h...

specific Embodiment 2

[0025] Specific embodiment 2: a kind of polylysine for stent coating, preparation method is as follows:

[0026] Step 1. Insert the bacterial strain into the culture medium and culture it at 25°C for 40 hours. The culture medium includes: 100 parts by weight of distilled water, 2 parts of glucose, 0.1 part of sodium chloride, calcium chloride : 0.1 part, ammonium chloride: 0.1 part, magnesium chloride 0.1 part, the pH value of the medium is 6.5.

[0027] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculum amount of 5%, and cultivate it at 25°C for 48 hours; the fermentation medium includes: 100 parts by weight of distilled water, 0.2 parts of peptone, and 0.2 parts of yeast extract part, 0.5 part of glycerol, 0.5 part of glucose, and the pH value of the fermentation medium is 6.5.

[0028] Step 3, centrifuging the above fermented liquid for 20 minutes, collecting the cells, heating in a water bath, taking the supernata...

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PUM

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Abstract

The invention discloses polylysine for support frame coating, and belongs to the field of medical use. A preparation method comprises the following steps of 1, inoculating strains into a culture medium for culture; performing culture for 40 hours at 25 to 30 DEG C; 2, inoculating the culture liquid into the fermentation culture medium according to the inoculating quantity of 5 percent; performingculture for 48 hours at 25 to 30 DEG C; 3, performing centrifugation on the fermentation liquid for 20 minutes; collecting cells; after the water bath heating, taking liquid supernatant; draining thewater; preparing polylysine; 4, dissolving 2-amino-3-hydroxyphenylpropionic acid monomers and peroxide initiators into an organic solvent to obtain a solution; then, mixing the obtained solution withthe prepared polylysine powder; performing grafting modification on the mixture through melt grafting reaction equipment to obtain polylysine grafting 2-amino-3-hydroxyphenylpropionic acid biodegradable polymers.

Description

technical field [0001] The present invention relates to the field of stents. Background technique [0002] Cardiac stent (Stent), also known as coronary stent, is a medical device commonly used in cardiac interventional surgery and has the function of dredging arteries. The main materials are stainless steel, nickel-titanium alloy or cobalt-chromium alloy. [0003] Existing metal stents easily lead to restenosis of blood vessels. In a new type of stent, anti-thrombotic and anti-proliferative drugs are wrapped on the heart stent. After the stent is implanted, the drug is released slowly, which can increase the local drug concentration, reduce side effects, and reduce the rate of restenosis. [0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In biodegradable polymer materials, the drug release rate is low and the effective time is short. Contents of the invention [0005] The object of the present invention is: to the abo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C12P13/02C09D177/04
CPCC08G69/48C09D177/04C12P13/02
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
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