Compound red sage root freezing-dried powder injection
A technology of freeze-dried powder injection and compound Salvia miltiorrhiza, applied in the field of medicine, can solve the problems of large dosage, inconvenience to carry, slow onset of effect, etc.
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Embodiment 1
[0176] a. Take 1000g of salvia miltiorrhiza, 850g of notoginseng and 5g of borneol for the prescription;
[0177] b. The above Danshen and Panax notoginseng were extracted twice with water, each time for 1 hour, the extracts were combined and concentrated to obtain the Danshen extract and Sanqi extract; the borneol was dissolved with an appropriate amount of ethanol, and clathrated with β-cyclodextrin;
[0178] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.
[0179] In the above-mentioned compound freeze-dried powder for injection, the content of borneol is calculated as D-borneol, and the content is measured according to gas chromatography (Appendix VIE of Chinese Pharmacopoeia 2005 edition).
[0180] Chromatographic conditions and system suitability t...
Embodiment 2
[0203] a. Take 4000g of salvia miltiorrhiza, 260g of notoginseng, and 50g of borneol for later use;
[0204] b. The above Danshen and Panax notoginseng were extracted with ethanol respectively to obtain Danshen extract and Sanqi extract; borneol was dissolved with an appropriate amount of ethanol and clathrated with β-cyclodextrin;
[0205] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.
[0206] Measure content according to embodiment 1 borneol content assay method, this product contains borneol with d-borneol (C 10 h 18 O), the content is 30.25~75.0mg / g freeze-dried powder solids.
[0207] Measure content according to the salvianolic acid B content assay method of embodiment 1, this product contains salvianolic acid B (C 36 h 30 o 16 ) is 30.25~55...
Embodiment 3
[0211] a. Take 1200g of salvia miltiorrhiza, 300g of notoginseng and 6g of borneol for later use;
[0212] b. The above Danshen and Panax notoginseng were extracted with water respectively, alcohol precipitation was carried out three times, the extracts were combined and concentrated to obtain the Danshen extract and the Sanqi extract;
[0213] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , made into 1000 bottles, that is to say.
[0214] Measure content according to embodiment 1 method, this product contains notoginseng and ginsenoside Rg1 (C 27 h 32 o 16 ), ginsenoside Rb1 and notoginsenoside R1, the content is 11.5-24.2mg / g freeze-dried powder solid.
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