Process for the preparation of antimicrobial mould inhibitor

A technology of antibacterial and antifungal agents and adhesives, which is applied in the field of preparation of antibacterial and antifungal agents, can solve the problems of chitosan’s bactericidal and antibacterial performance reduction, composite film’s unsatisfactory bactericidal ability, limited application range, etc., and achieve good sterilization and antifungal properties. Mildew effect, good timeliness, wide application range

Inactive Publication Date: 2008-02-06
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the antibacterial coating of the above literature, the bactericidal effect is mainly enhanced by adding silver ions and nano-titanium dioxide composites. The antibacterial effect of silver ions is very strong, but its chemical properties are active, and it is easy to transform into brown silver oxide or reduce to black elemental silver. , the discoloration occurs
In addition, the cost of using a large amount of silver is very high, and it is harmful to the human body, which limits its application.
[0003] In recent years, polysaccharide biomaterials such as chitosan have been valued and applied due to their excellent properties such as biodegradation, regeneration, antibacterial and antiseptic, and good film-forming properties. Poisonous and environmentally friendly antibacterial materials have opened up new ways, such as: Dong Zhanfeng et al. in "Journal of Functional Polymers" in December 2002, Volume 48, No. 6 "Chitosan / nano-TiO 2 Preparation and Performance Research of Composite Membranes" and "Chitosan / Gelatin / TiO 2 In "Preparation and Functional Research of Ternary Composite Membranes", it is proposed to use chitosan and anion-modified nano-TiO 2 , a new type of degradable antibacterial composite packaging film was prepared by the solution blending method. This method added natural polymers such as gelatin to improve the mechanical properties of the film. However, since these natural polymers are the nutrient source for bacteria, chitosan The bactericidal and antibacterial performance has been reduced, so the bactericidal ability of the composite film is not ideal, and the composite film is mainly used to prepare antibacterial packaging bags, the scope of use is limited, and the processing cost is high

Method used

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  • Process for the preparation of antimicrobial mould inhibitor
  • Process for the preparation of antimicrobial mould inhibitor
  • Process for the preparation of antimicrobial mould inhibitor

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1: 0.1g hydroxypropyl ethyl cellulose is dissolved in 10g hydrochloric acid, then add 1g particle diameter and be less than 100nm German production P25 type nano-titanium dioxide, after mixing, add 10ml glutaraldehyde, stir, rotating speed 20 revs / min, exchange The joint reaction was carried out for 0.5 hours at a temperature of 80°C. After cross-linking, let it stand for defoaming, apply a film, and get a new type of antibacterial and antifungal agent after air-drying. Spread the bacterial liquid evenly on the glass slide coated with a new antibacterial and antifungal agent, after 0, 2, 4, 8, 12, and 24 hours, gently wipe the bacterial liquid with a cotton swab and place it in normal saline. Oscillate, take 0.3ml in the petri dish, pour into the culture medium, cultivate in the incubator for 48 hours, take out the number of colonies, the sterilization rate is respectively 90%, 95%, 98%, 98%, 98%.

Embodiment 2

[0026] The operating method of embodiment 2 and embodiment 3 is the same as embodiment 1, and the operating parameters are shown in table 1.

Embodiment 4

[0027] Embodiment 4: Dissolve 0.1g carboxymethyl chitosan in 10g nitric acid, add 0.01g ethyl cellulose, add 1g particle diameter and be less than 20nm Japanese nano titanium dioxide after mixing for 12 hours, add 10ml ethylene glycol after mixing Bis-glycidyl glycidyl ether, stirred at a speed of 20 rpm, crosslinked for 0.5 hours, at a temperature of 80°C. After cross-linking, let it stand for defoaming, apply a film, and get a new type of antibacterial and antifungal agent after air-drying. Spread the bacterial liquid evenly on the glass slide coated with a new antibacterial and antifungal agent, after 0, 2, 4, 8, 12, and 24 hours, gently wipe the bacterial liquid with a cotton swab and place it in normal saline. Oscillate, get 0.3ml in the petri dish, pour into the medium, cultivate in the incubator for 48 hours, take out the number of colonies, the sterilization rate is respectively 96%, 98%, 99%, 99%, 99%.

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Abstract

The invention relates to a preparation method of an antisepsis and antimildew agent. The preparation method is that: polysaccharid water solubility adhesive agent is dissolved in an acid solution and then nanometer titanium dioxide is added into the acid solution, each one gram of the adhesive agent is added with 0.01 to 10 grams of the nanometer titanium dioxide, at last the mixed agent is added with an organic cross-linking agent to make the antisepsis anti mildew agent, each one gram of the adhesive agent is added with 0.1 to 100 ml of the organic cross-linking agent, during the preparing process of the invention, the antisepsis and antimildew agent can be added with cellulosic latex, metallic ions and high molecule sterilization auxiliary agent etc., which results in synergistic effects of a plurality of bactericidal agents, in addition, dried and formed into film, the invention which is coated on the surfaces of articles has antisepsis and mildew proof effects. Within two hours after using the invention, the sterilizing rate is more than 90 percent, the sterilizing rate is nearly 100 percent within four hours, and the sterilizing rate can be maintained more than 90 percent within twenty-four hours, resulting from time efficiency of the invention.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial and antifungal agent, in particular to the preparation of an antibacterial and antifungal agent containing nano-titanium dioxide. The obtained antibacterial and antifungal agent can be sprayed on the surface of articles requiring antibacterial to form a film to sterilize and prevent mildew. Background technique [0002] Nano-TiO2 is a non-eluting antibacterial agent based on photocatalytic reaction to decompose organic matter and has antibacterial effect. It has good chemical stability, non-toxicity, low heavy metal content, broad-spectrum and long-term antibacterial properties. The more widely used in people's daily life. At present, there are antibacterial products prepared by using nano-titanium dioxide. Generally, nano-TiO2 sol is used to treat the surface of objects. For example, Cui Zuolin, Yu Zida, and Zhang Zhikun proposed a nano-TiO2 2 The preparation method of the sol (applic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N25/24A01P1/00A01N33/02
Inventor 苏海佳赵艳谭天伟
Owner BEIJING UNIV OF CHEM TECH
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