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New use of tree peony oil in decreasing blood sugar and slimming

A peony oil and blood lipid technology, which is applied in medical preparations containing active ingredients, cardiovascular system diseases, plant raw materials, etc., can solve the problem of insufficient development and utilization of peony seed oil

Inactive Publication Date: 2008-02-27
TONGLING KIARUN PEONY BIOLOGICAL MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, peony seeds are only used in a small amount for reproduction, while peony seed oil with high nutritional and medicinal value has not been fully developed and utilized

Method used

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  • New use of tree peony oil in decreasing blood sugar and slimming
  • New use of tree peony oil in decreasing blood sugar and slimming

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: Effect of peony oil on blood lipid level of normal rats

[0026] Take normal Wistar (200±20g, ) 48 rats were randomly divided into normal control group, peony oil 0.56, 1.68, 5.04g / kg three dosage groups and lovastatin 0.01g / kg, linoleic acid 1.40g / kg positive drug control group. After taking the drug for 15 days and fasting for 8 hours on the 15th day, blood was taken from the inner canthal venous plexus, and the serum was collected by centrifugation. The content of triglyceride (TG) and cholesterol (TCH) in the serum was measured, and the lipid-lowering percentage of the drug was calculated at the same time.

[0027] Wherein, peony oil is prepared as follows:

[0028] A. Peony seeds cleaning→crushing and shelling→stir-fry until lightly crushed to remove the shells. Put the peony kernels into the press, heat at 80°C for 1-2 hours, and use a 200-type screw press to press. Oil and fritters.

[0029] B. The crude oil is filtered through a Buchner funnel ...

Embodiment 2

[0036] Embodiment 2: Effect of peony oil on normal rat body weight

[0037] Take normal Wistar (200±20g, ) 48 rats were randomly divided into normal control group, peony oil 0.56, 1.68, 5.04g / kg three dosage groups and lovastatin 0.01g / kg, linoleic acid 1.40g / kg positive drug control group. After taking the medicine for 15 days, after fasting for 8 hours on the 15th day, the body weight was weighed, and compared with that before administration, the body weight change was investigated. The results are shown in Table 2.

[0038] Table 2 The effect of peony oil on the body weight of normal rats (x±s, n=8)

[0039] group

Dose (g / kg)

Weight Δ(g)

normal group

high dose group

Middle dose group

low dose group

lovastatin group

Linoleic acid group

-

5.04

1.68

0.56

0.01

1.40

39.63±8.64

36.13±8.14

28.38±7.52 **

23.88±10.47 ***

25.00±11.46 **

29.12±9.51 *

[0...

Embodiment 3

[0042] Example 3: Effect of prophylactic administration of peony oil on blood lipid levels in hyperlipidemic rats

[0043] Take normal Wistar (200±20g, ) 56 rats were observed in the experimental environment for 7 days, and then the rats were randomly divided into 7 groups: normal control group, model group, peony oil 0.56, 1.68, 5.04g / kg three dosage groups and lovastatin 0.01g / kg, linoleic acid 1.40g / kg positive drug control group, every group of 8, except that the normal group is given normal feed, all the other groups are given high-fat feed (4% cholesterol+10% lard+0.2% methyl thiouracil+85.8% basal feed). The treatment group was given different doses of the test drug while giving the high-fat feed, and the drug was administered continuously for 15 days. On the 15th day, weighed, after fasting for 8 hours, blood was taken, and the supernatant was obtained by centrifugation to measure TG, TCH, HDL-C, LDL-C, FFA content, measure the rat body length (length from nose to a...

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Abstract

The invention relates to the novel use of peony oil in lowerying blood fat and fat-reducing. Test results show that, peony oil has better treatment action for various hyperlipemia diseases and related diseases than linoleic acid groups.

Description

technical field [0001] The invention provides a new application of peony oil, in particular, provides the application of peony oil for lowering blood fat and reducing weight. The test results of the present invention show that the tree peony oil has significant therapeutic effect on various types of hyperlipidemia and related diseases, which is significantly stronger than that of the linoleic acid group. It belongs to the field of medicine. Background technique [0002] Since the 1990s, with the continuous increase of my country's national income and the rapid improvement of living standards, the number of patients with hyperlipidemia and obesity has increased rapidly. Hyperlipidemia often causes a series of diseases, including high-risk diseases such as atherosclerosis, coronary heart disease, stroke, and myocardial infarction. Clinically, according to the determination results of serum total cholesterol, triglyceride and high-density lipoprotein-cholesterol, hyperlipidem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P1/16A61P3/04A61P3/06A61P9/10A61K131/00
Inventor 李晓祥宋波牧贤贵权春明
Owner TONGLING KIARUN PEONY BIOLOGICAL MEDICINE TECH
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