The invention discloses a processing method of a rubus rosaefolius smith-pomegranate seed nutritional powder. The rubus rosaefolius smith-pomegranate seed nutritional powder takes rubus rosaefolius smith and pomegranate seed as main raw materials, and is processed by the steps of raw material preparation, composite enzyme treatment, ultrasonic extraction, blending, homogenization, degassing and sterilization, concentration and drying, crushing and filtering and the like. Raw materials are soaked with a soaking liquid after the raw materials are mixed, so that the loss of nutrient substances is avoided; beating is carried out after soaking, the slurry is subjected to composite enzyme treatment, decomposition of raw material tissue cells is promoted, the separation efficiency of the raw material nutrient substances is increased, and thus the utilization rate of the raw materials is increased, and the finished product rubus rosaefolius smith-pomegranate nutritional powder is balanced in nutrition, delicious in taste, and bright and shining in color and luster, and has the health-care functions of clearing away heat and toxic materials, promoting blood circulation to arrest pain, calming liver and refreshing blood, beautifying features and nourishing face and the like.