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Wound dressing of povidone iodine hydrogel and radiation preparation method of the same

A technology of povidone-iodine and wound dressing, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of inability to achieve controlled drug release, high water solubility, and weakened bactericidal ability, and achieve long-lasting drug action, Reduces pain and reduces mechanical damage

Inactive Publication Date: 2008-02-27
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is high water solubility, which cannot realize the controlled release of drugs, and the bactericidal ability gradually weakens with time, and the product is not suitable for various wound dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 15g of povidone-iodine and dissolve it in 50g of deionized water, stir for 10min to make a uniform povidone-iodine aqueous solution; dissolve 5g of polyvinyl alcohol with a degree of polymerization of 1750 in 150g of deionized water at 95°C, after completely dissolving, Cool to 50°C, add 10g of polyvinylpyrrolidone, 6g of gelatin, 4g of glycerin and 5g of 2% citrate buffer solution, stir for 1 hour to dissolve completely, and after forming a uniform solution, slowly add Into the prepared povidone-iodine aqueous solution, after mixing evenly, vacuumize and defoam. After defoaming, inject to 12×8×1.5mm 3 Immediately freeze at -5°C for 14 hours, and then thaw at room temperature for 10 hours. This cycle of freezing and thawing is repeated twice. After packaging with brown PE film, use it at room temperature 60 Co gamma-ray irradiation 20kGy, povidone-iodine hydrogel wound dressing can be prepared, and the product is a uniform brown-red film.

[0025] The cross-link...

Embodiment 2

[0027] Weigh 15g povidone iodine and dissolve it in 50g deionized water, stir for 10min to make a uniform povidone iodine aqueous solution; mix 10g polyvinylpyrrolidone, 20g acrylic acid, 0.4g N, N'-methylenebisacrylamide and 4g Glycerin was dissolved in 110g deionized water respectively, after completely dissolving, slowly added to the prepared povidone-iodine aqueous solution under stirring, after mixing evenly, injected into 12×8×1.5mm 3 Immediately freeze at -7°C for 10 hours in a plastic mold, then thaw at room temperature for 10 hours, repeat the freeze-thaw cycle twice, use brown PE film to package, and use 60 The povidone-iodine hydrogel wound dressing can be prepared by irradiating 10kGy of Coγ-rays. The product is a uniform brown-red film with a crosslinking degree of 88% and an equilibrium water absorption rate of 353.6%.

Embodiment 3

[0029] Weigh 20g of povidone-iodine and dissolve it in 70g of deionized water, stir for 10 minutes to make a uniform povidone-iodine aqueous solution; dissolve 10g of polyvinyl alcohol with a degree of polymerization of 1750 in 120g of deionized water at 95°C, , cooled to 40°C, respectively added 10g of polyvinylpyrrolidone, 10g of polyethylene oxide, 8g of 15% carboxymethyl cellulose, 6g of glycerol and 4g of 2% citrate buffer solution, stirred for 1h to make it completely After dissolving to form a uniform solution, slowly add it into the prepared povidone-iodine aqueous solution under stirring, and after mixing evenly, vacuumize and defoam. After defoaming, inject to 12×8×1.5mm 3Immediately freeze at -3°C for 16 hours, and then thaw at room temperature for 12 hours. This freeze-thaw cycle is repeated twice. After packaging with brown PE film, put the pre-fabricated film into the electron accelerator, at 1.5MV and 10mA Under the conditions of irradiation, the absorbed dose ...

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Abstract

The invention discloses a polyweitone iodine solution gel wound dressing and dressing making method, which comprises the following parts: 1-10% polyweitone iodine, 10-30% crosslinking hydrophilic polymer, 1-5% irradiation sensitizer, 1-5% plasticizer and water, wherein the pH value of the solution is maintained within 6-8. The making method comprises the following steps: blending gel material and water evenly; extracting into vacuum to debubble; freezing; solidifying; moulding; selecting the irradiation dose at 10-100kGy to crosslink irradiated by 60Co gamma-ray or electronic beam. The invention is fit for healing the burnt, superficial ulcer, superficial injury due to trauma and surgery, which antibioses and lessens pain to accelerate the healing of wound and reduce the formation of scar.

Description

Technical field: [0001] The invention relates to a composition of a novel biomedical polymer material and a preparation method thereof, in particular to a povidone-iodine hydrogel wound dressing with antibacterial and wound healing functions and a radiation preparation method thereof. Background technique: [0002] Wound dressings have developed greatly in recent decades, and many new types of dressings have appeared, especially wound dressings with hydrogel as the main component. Because they can absorb wound exudate, they can keep the wound clean and moist, and reduce Scar formation, which can prevent bacterial invasion, prevent infection, and promote wound healing, has attracted more and more attention. It is especially suitable for the protection and treatment of burns, scalds, chemical erosions, ulcers, various external traumas, burns and surgical injuries. Chinese patent CN1679972A discloses a gradient shell hydrogel wound dressing and a preparation method thereof, wh...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/24A61L15/26
Inventor 朱诚身杨明成何素芹刘文涛
Owner ZHENGZHOU UNIV
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