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Retinene membrane protein and groundmass composite material, and method of producing the same

A composite material, retinal technology, applied in the field of retinal membrane protein and matrix composite materials and their preparation, can solve problems such as destruction, data error, unfavorable preservation and the like

Inactive Publication Date: 2008-02-27
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there will be some problems in the preparation process, such as protein molecule aggregation due to phase separation, and the drying process must strictly control temperature and humidity, otherwise protein molecules will diffuse to the surrounding membrane with water volatilization, both of which are Greatly affects the uniformity of the dry film
The formation of the above composite film is based on the interaction between the van der Waals force or hydrogen bond between the matrix molecules. There is no chemical bond connection, and it is easy to lose its original shape or even be destroyed by external influences.
In addition, because the protein molecules are only dispersed in the matrix and are not fixed, after the data is recorded, the protein molecules will move as the carrier of the data, resulting in data errors and loss, which is not conducive to long-term storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Bacteriorhodopsin-gelatin cross-linked composite film

[0019] Weigh 1g of gelatin particles, add it to 10mL water, stir in a hot water bath at 60°C until completely dissolved, and obtain a gelatin solution with a concentration of 10% (wt). 1 m 1 The bacteriorhodopsin protein extracted from the lyophilized protein was freeze-dried into a dry powder, weighed 40mg of the dry protein powder and suspended it in 0.5mL water, and ultrasonically dispersed it on a YJ92-II ultrasonic cell pulverizer with a power of 100w, an ultrasonic time of 5s, and an interval of 30s, and ultrasonicated 15 times. Take 0.5 mL of 10% gelatin solution, add it to the protein suspension, stir and mix in a hot water bath, and then ultrasonically disperse again, with a power of 100w, ultrasonic time of 5s, interval of 30s, and ultrasonication 15 times to obtain a clear and transparent mixed solution. Filter the mixed solution through an ester microporous membrane, place it in a hot water bath, weigh...

Embodiment 2

[0021] Bacteriorhodopsin D96N Mutant-Gelatin Crosslinked Composite Film

[0022] Weigh 2 g of gelatin particles, add them to 10 mL of water, stir in a hot water bath at 60°C until completely dissolved, and obtain a gelatin solution with a concentration of 20% (wt), freeze-dry the bacteriorhodopsin D96N mutant protein into a dry powder, and weigh the protein dry powder Suspend 5mg in 0.5mL water, ultrasonically disperse on a YJ92-II ultrasonic cell pulverizer, power 150w, ultrasonic time 4s, interval 40s, ultrasonication 10 times, absorb 0.5mL 20% gelatin solution, add to the protein suspension, put in a hot water bath Stir and mix, ultrasonically disperse again, power 150w, ultrasonic time 3s, interval 50s, ultrasonic 10 times to obtain a clear and transparent mixed solution, filter the mixed solution with a 5 μm cellulose ester microporous membrane while it is hot, place it in a hot water bath, weigh Take 10 mg of EDC, dissolve it with a small amount of water, add it to the m...

Embodiment 3

[0024] Composite Membrane Containing Archaeordopsin 4

[0025] Weigh 3 g of acrylamide (acr for short), 8 mg of N,N-methylene-bisacrylamide (Bis for short), dissolve them in 10 mL of water to obtain a monomer solution with a concentration of 30% (wt), store at 4°C, The ancient rhodopsin 4 protein extracted from strain xz515 was freeze-dried into dry powder, weighed 15mg of protein dry powder, added to 1mL of 30% acrylamide monomer solution, stirred and mixed, and ultrasonically dispersed on a YJ92-II ultrasonic cell pulverizer, power 200w, ultrasonic time 3s, interval 50s, ultrasonication 5 times to obtain a clear and transparent mixed solution, filter the mixed solution with a 5μm cellulose ester microporous membrane, weigh 8mg of EDC, 1mg of ammonium persulfate (ammonium persulfate referred to as AP), and use a small amount of water After dissolving, add it to the mixture, stir gently to avoid air bubbles, absorb an appropriate amount of liquid, spread it in a circular membr...

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PUM

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Abstract

The invention discloses a retinyl membrane protein and composite base material and making method, which is characterized by the following: blending the separated and purified retinyl membrane protein with optical information storage and disposing information and the base with multi-functional group material; using crosslinking technique to form the chemical crosslinking network through chemical bond connection between active protein molecule and base molecule; drying; obtaining the even, flat, stable and easily manufactured and preserved composite material with active protein; fitting for storing and disposing the optical information with good stability and safety of data storage.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and information materials, and specifically relates to a retinal membrane protein and matrix composite material and a preparation method thereof. Background technique [0002] In the field of light storage and processing, retinal proteins with photoactive responses include bacterial rhodopsin (bacteriorhodopsin, BR), archaerhodopsin (AR, such as AR4, see Li, Q.G. et al, BBA1466, 260-266, 2000; Ming, M.Biophys.J.90, 3322-3332, 2006) and their mutants are all functional proteins with good application prospects, and the composite films prepared by mixing them with polymers can be used in optical Information storage (including two-dimensional storage, three-dimensional storage and holographic storage, etc.) and optical information processing (including light conversion, light filtering and signal conditioning, etc.). (Hampp, N. Chem. Rev. 2000, 100, 1755-1776). [0003] In the past, compos...

Claims

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Application Information

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IPC IPC(8): C08L101/00C08J3/24C08K5/16C07K14/195
Inventor 丁建东吴佳
Owner FUDAN UNIV