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Preparation of molecule marking polymer capable of removing penicillins antibiotics in fresh milk

A technology of penicillin and molecular imprinting, which is applied in the field of food chemistry, can solve the economic loss of dairy processing enterprises, milk safety concerns, and unsolved problems, and achieve the effect of simple and easy to master preparation methods, reduce costs, and reduce waste

Inactive Publication Date: 2010-05-12
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the past, there were no explicit regulations on the sanitary indicators of antibiotic residues in milk in my country. Until October 2001, the Ministry of Agriculture issued and implemented the "Industry Standards for Pollution-Free Food Raw Milk", which clarified the hygienic indicators of fresh milk that "antibiotics must not be detected". An industry standard, but our country has not strictly implemented it, resulting in the problem of antibiotic residues in milk and dairy products in our country has not been resolved, and has caused people to worry about the safety of milk
[0005] In short, milk contains antibiotics, which not only cause great harm to human health, but also bring economic losses to dairy processing enterprises (because yogurt and cheese cannot be produced). Therefore, antibiotic residues in milk must be strictly controlled. In addition to scientific Breeding and careful management; apart from correct milking and disease prevention, the use of antibiotics must also be regulated. According to the relevant regulations in the national standard, the milk produced by the cows after 5 days of treatment can be used as raw milk and its residues should be tested. World Food and Agriculture Organization (FAO), the World Health Organization (WHO), the European Union (EC) and the Food and Drug Administration (FDA) of the United States all have clear regulations on the maximum residues (MRL) of antibiotics in food. China also has antibiotics residues in fresh milk. Quantitative inspection standard (GB4689, 27-94). At present, the detection and control of antibiotic residues in fresh milk is a complicated process. Although we have a relatively good detection method, we are only satisfied with the detection of antibiotic residues in milk It is far from enough. What kind of treatment the tested milk will go through and what kind of supporting treatment means are also important. Therefore, the present invention proposes a new idea that can remove antibiotics in milk, that is, adopt Molecularly imprinted polymer technology to remove antibiotics in fresh milk is a technological innovation with practical significance.

Method used

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Embodiment Construction

[0020] The present invention is further described in detail through the following examples, but the technical content described in this example is illustrative rather than limiting, and should not limit the protection scope of the present invention accordingly.

[0021] The best embodiment: take 0.5mmol of the template molecular compound penicillin and dissolve it in 5mL of inert solvent N, N-dimethylformamide solution, add 2.0mmol of functional monomer methacrylic acid (MAA), place on a shaker to vibrate 6h, so that the template molecules and functional monomers fully act. Then add cross-linking agent ethylene glycol dimethacrylate (EDMA) 10mmol, initiator azobisisobutyronitrile (AIBN) of 0.0125g, transfer to a 15mL test tube after mixing, nitrogen deoxygenation 10min, seal under vacuum Then put it in a constant temperature water bath, react at 60°C for 24 hours to form a rod-shaped polymer, and then crush and grind the polymer with a mortar and sieve. : 1)] ultrasonic washi...

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Abstract

The present invention relates to a preparation method for molecular imprinted polymer which can get rid of the penicillin-like antibiotics in the fresh milk. The present invention belongs to the foodchemistry field. The preparation method lie in that template molecule, functional monomer, cross-linking agent and the initiator are mixed together to be oxygenated, thermal polymerized, grinded, cleaned and dried in vacuum to get molecular imprinted polymer. The present invention is simple and controllable. The required experimental devices are simple. The generated molecular imprinted polymer isof strong stability, long storage time, large adsorption capacity and fast adsorption speed. The counter- imprinted molecular is of strong memory and no toxin and any side effect. The molecular imprinted polymer can effectively get rid f the penicillin-like antibiotics in the fresh milk and can be used in the examination of penicillin-like antibiotics in the fresh milk. The present invention is of very broad prospects for development and application.

Description

Technical field: [0001] The invention relates to the field of food chemistry, in particular to a method for preparing a molecularly imprinted polymer capable of removing penicillin antibiotics in fresh milk. Background technique: [0002] According to the results of a survey conducted by the General Administration of Quality Affairs of the People's Republic of China on the northern Chinese market, among nearly 800 samples of dairy products, antibiotic residues exceeded the standard among the unqualified items of dairy product quality; Sampling inspections have been carried out, and the positive detection rate of antibiotic residues in some provinces and cities is as high as 30%. From this point of view, the status quo of antibiotic residues in milk in my country is not optimistic. The main sources of antibiotics in raw milk are: first, the antibiotics used to treat sick cows during lactation will be excreted from the cows; Antibiotic residues; Third, due to poor management o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/06C08F2/44C08F4/04C08F8/00C08J9/24A23L1/015A23C7/04G01N33/04A23L5/20
Inventor 张娟琨王慧张伟亮董杉木
Owner TIANJIN UNIV OF SCI & TECH
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