Method for preparing micrometer and submicron probe arrays

A submicron, needle array technology, applied in the field of preparation of nano- and micro-structured materials, can solve problems such as limiting the application field and scope, and achieve the effects of short preparation cycle, simple operation, and reduced preparation cost

Inactive Publication Date: 2008-03-19
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, this greatly limits its application field and scope

Method used

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  • Method for preparing micrometer and submicron probe arrays

Examples

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Effect test

Embodiment 1

[0020] Example 1: SiO with a diameter of 8 microns 2 Fiber obtains SiO through self-assembly technology 2 Fiber bundle; then put it into the MMA (polymethyl methacrylate) solution with BPO, place it in a water bath and heat it at 60℃ for 24h to solidify the polymer, SiO 2 The volume ratio of the fiber bundle to the polymer cured product is 0.1; then, it is cut into slices with a thickness of 1 mm, and then corroded with a 40% HF acid solution at a constant temperature of 30°C for 5 minutes, ultrasonically cleaned with deionized water, and dried to obtain a nanoneedle array.

Embodiment 2

[0021] Example 2: SiO with a diameter of 8 microns 2 Fiber obtains SiO through self-assembly technology 2 The fiber bundle; then put it into the styrene solution added with hexamethyleneimine lithium, and heat it in a water bath at 60℃ for 24h to solidify the polymer; SiO 2 The volume ratio of the fiber bundle to the polymer cured product is 0.3; then it is cut into slices with a thickness of 3mm; it is corroded with a 20% HF acid solution at a constant temperature of 30°C for 30 minutes, ultrasonically cleaned with deionized water, and dried to obtain a nanoneedle array;

Embodiment 3

[0022] Example 3: SiO2 fibers with a diameter of 8 microns are obtained by self-assembly technology 2 Fiber bundle; then immerse it in the molten resin at 120℃, and cool the slice after filling, SiO 2 The volume ratio of the fiber bundle to the polymer cured product is 0.6; the slice thickness is 1cm; it is etched with 40% HF acid solution for 10 minutes at a constant temperature of 40°C, and then cleaned with deionized water ultrasonically. After drying, the nanoneedle array can be obtained, as shown in Figure 2.

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Abstract

The invention discloses a method of preparing a micrometer and sub-micrometer needle array. The method adopts the self-assembly technology and integrates the filling, cutting and controllable corrosion technologies. First, the self-assembly technology is adopted to technically assemble the micrometer/sub-micrometer fiber; and then the polymeric compound is filled, finally the micrometer and sub-micrometer needle array is prepared by the cutting and the controllable corrosion technologies. The invention has the advantages of low cost, no need of complicate equipments and technologies, capability of quick batch production, large area of needle array, smooth needle surface, adjustable diameter, length and taper, etc., and is widely applicable in the detecting, sensing, optical, biology and medicine fields, etc.

Description

Technical field [0001] The invention relates to a method for preparing nanometer and micrometer microstructure materials, in particular to a method for preparing micrometer and submicron needle arrays. Background technique [0002] The preparation of micron and submicron needle arrays is a technology with important application background. In the optical field, the micro / submicron needle array can be used as a near-field optical probe to obtain near-field optical information; in the field of biomedicine, the micro-needle array is mainly used for subcutaneous painless drug delivery, subcutaneous painless tissue fluid extraction, etc. Oral administration stimulates the gastrointestinal tract, intramuscular injection cannot be continuously administered, and external application is difficult to achieve the required dose due to the barrier of the stratum corneum. Since the current preparation of microneedle arrays mainly relies on micro-processing techniques, such as reactive ion beam ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81C5/00B81C99/00
Inventor 祝名伟唐月锋陈延峰闵乃本
Owner NANJING UNIV
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