Casein phosphopeptide cyclodextrin inclusion compound without bitter and its preparation method

Abstract

The present invention relates to a casein phosphopeptide cyclodextrin clathrate and its preparation method. Said preparation has good action for promoting calcium absorption and utilization, raising bone density and preventing the diseases of osteoporosis and rachitis, and said preparation can be made into injection preparation, and the weight ratio of casein phosphopeptide: cyclodextrin=1:0.1-30.

Description

technical field [0001] The invention relates to a non-bitter casein phosphopeptide inclusion compound and a preparation method thereof. The substance has the health care function of promoting the absorption of calcium and iron divalent ions and increasing bone density, and belongs to the technical field of medicine and health food. Background technique [0002] Casein phosphopeptides are phospho-serine-rich polypeptide substances separated and purified from casein after proteolysis. The English name is Casein phosphopeptides, or CPP for short. CPP can combine with divalent mineral ions such as calcium and iron in the small intestine environment to prevent precipitation and increase the concentration of soluble minerals, thereby promoting their absorption and utilization, increasing bone density, and preventing children's rickets, middle-aged and elderly osteoporosis and other diseases . Casein phosphopeptides were first discovered in the 1950s. In the future, the research ...

AI Technical Summary

Problems solved by technology

The structure is rich in phosphoserine. Due to the large number of small peptide sequences produced by protease hydrolysis, some of these peptides contain amino acids with heavy bitterness and may be exposed in the chemical structure. Therefore, CPP products usually have heavy bitterness and peculiar smell. It is more obvious in low-purity products, which greatly limits the application of the product

The current CPP method for removing bitterness, one is to improve the purity of the product, but this is often expensive, which makes the cost of CPP high, and removes some effective active substances in CPP, and the other is to separate and remove bitter substances, but now Some processes are often incomplete in deodorization, while the cost is still high, and some effective active substances are also removed

Adopt gac or ion resin deodorization method as Japanese Patent Laid-Open No. 59-159792 report, yield is lower, and cost is higher