Hollow polymer sub-micron sphere coated with gold case and preparation method

A polymeric, submicron technology with applications in the field of nanomaterials

Inactive Publication Date: 2010-07-14
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In these methods, the optical properties of metal hollow materials are mostly studied, but the application of metal hollow nanomaterials in drug loading and controlled release and combined with metal plasmon resonance has not been reported. The present invention uses polymer spheres as templates , the prepared hollow gold shell submicron spheres can not only precisely adjust the position of its plasmon resonance peak, but also can carry out drug loading and control the slow release of drugs, especially in the treatment of malignant tumors, it has broad application prospects

Method used

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  • Hollow polymer sub-micron sphere coated with gold case and preparation method
  • Hollow polymer sub-micron sphere coated with gold case and preparation method
  • Hollow polymer sub-micron sphere coated with gold case and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0046] (1) To prepare colloidal gold, in a certain amount of aqueous solution, HAuCl 4 The concentration range is 10 -7 mol / L, the concentration of sodium citrate is 10 -7 mol / L, adding a certain amount of sodium borohydride (NaBH 4 ) after stirring to disperse, NaBH 4 The concentration is 10 -6 mol / L.

[0047] (2) Functionalization of polymer spheres

[0048] i) preparation polyelectrolyte solution, chitosan is dissolved in the mass concentration and is made into solution A in the acetic acid of 0.1%, and chitosan concentration is 10 -2 mol / L, put 10 -2 mol / L polyacrylic acid aqueous solution as solution B.

[0049] ii) Disperse polystyrene submicron spheres with a particle size of 50nm in a buffer solution of acetic acid / sodium acetate at pH=3.6, the concentration of polymer submicron spheres in the buffer solution is 100mg / ml; add a certain amount of polycation Solution A, so that the concentration of chitosan in the system reaches 10 -4 mol / L, stirred and adsorbed...

Embodiment 2

[0063] (1) To prepare colloidal gold, in a certain amount of aqueous solution, HAuCl 4 The concentration range is 10 -4 mol / L, the concentration of sodium citrate is 10 -4 mol / L, adding a certain amount of sodium borohydride (NaBH 4 ) after stirring to disperse, NaBH 4 The concentration is 10 -3 mol / L.

[0064] (2) Functionalization of polymer spheres

[0065] i) Prepare a polyelectrolyte solution, dissolving poly(allylaminehydrochloride), PAH) in water to form solution A, the concentration of PAH is 1mol / L. Poly(styrenesulfonate), PSS) was formulated into an aqueous solution at the same concentration to form solution B (1 mol / L).

[0066] ii) Disperse polystyrene submicron spheres with a particle size of 1000nm in a buffer solution composed of disodium hydrogen phosphate / citric acid at pH=3.6, the concentration of polymer submicron spheres in the buffer solution is 10mg / ml; add A certain amount of polycation solution A, so that the polycation concentration in the syste...

Embodiment 3

[0079] (1) To prepare colloidal gold, in a certain amount of aqueous solution, HAuCl 4 The concentration range is 2×10 -5 mol / L, the concentration of sodium citrate is 5×10 -5 mol / L, adding a certain amount of sodium borohydride (NaBH 4 ) after stirring to disperse, NaBH 4 The concentration is 2×10 -4 mol / L.

[0080] (2) Functionalization of polymer spheres

[0081] i) prepare polyelectrolyte solution, chitosan is dissolved in the acetic acid that mass concentration is 5% and is made into solution A, and chitosan concentration is 10 -3 mol / L, put 10 -3 mol / L sodium alginate aqueous solution as solution B.

[0082] ii) dispersing polymethyl methacrylate (PMMA) submicron spheres with a particle size of 300nm in an acetic acid / sodium acetate buffer solution with pH=3.6, the concentration of the polymer submicron spheres in the buffer solution being 1 mg / ml; Add a certain amount of polycation solution A to make the polycation concentration in the system reach 10 -5 mol / L,...

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Abstract

The invention belongs to the nanometer material technical field, in particular to gold shell coated hollow polymer sub micrometer sphere, and the preparation method and the purpose thereof. The invention takes the polymer sub micrometer sphere as a template, and takes multi-layer coated polyelectrolyte as functional material, and the surface is uniformly coated with gold shells. The dimension of the hollow gold shell sub micrometer sphere and the thickness of the gold shell of the invention can be uniformly controlled. At the same time, according to the Mie scatting theory, the gold shell coated hollow polymer sub micrometer sphere can adjust the absorption in the near infrared region, can convert the optical energy of near infrared laser into the peripheral heat energy, can be applicablefor the heat sensitive material of cancer treatment, and can be applicalbe for killing malignant tumor cells. The material of the invention can combine a thermotherapy with the slow release of anti-tumor drug to be used for the cancer treatment.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, in particular to a gold-shell-coated hollow polymer submicron sphere, a preparation method and application thereof. Background technique [0002] The famous Nobel laureate Feyneman predicted in the 1960s that if some kind of control is applied to the arrangement of the object on a small scale, the object can obtain a large number of unusual characteristics. The materials he mentioned are now nanomaterials. Due to their unique physical and chemical properties, nanomaterials have become a hot spot in material science research. The study and application of the unique properties and mechanisms of nanomaterials has become the core content of nanoscience and technology. [0003] Metal nanoparticles exhibit many superior properties not possessed by bulk materials, and can be used in catalysis, photocatalysis, fuel cells, chemical sensing, nonlinear optics, information storage, etc. The unique o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08J7/04C08L25/06C08L33/12B32B27/00B32B33/00A61K9/14A61P35/00
Inventor 唐芳琼刘惠玉陈东孟宪伟
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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