Thermo-sensitive biodegradable polyanhydride copolymer as well as aquogel system and uses thereof

A biodegradable, polyanhydride technology, applied in the direction of drug delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc., to achieve the effect of simple and convenient operation

Inactive Publication Date: 2008-05-14
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, block copolymer in situ gel materials with polyanhydride as hydrophobic segment have not been reported yet.

Method used

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  • Thermo-sensitive biodegradable polyanhydride copolymer as well as aquogel system and uses thereof
  • Thermo-sensitive biodegradable polyanhydride copolymer as well as aquogel system and uses thereof
  • Thermo-sensitive biodegradable polyanhydride copolymer as well as aquogel system and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Raw materials: sebacic acid, D, L-lactic acid, polyethylene glycol monomethyl ether with a relative molecular mass of 5000 (MPEG 5000)

[0038] Add acetic anhydride and sebacic acid into the reaction vessel at a ratio of 10:1 (volume / mass, ml / g), reflux at 140°C for 40 minutes, then distill off acetic anhydride and the generated acetic acid under reduced pressure, add Toluene was dissolved and recrystallized by cooling, washed with a large amount of diethyl ether and petroleum ether mixed solvent with a volume ratio of 1:1, and dried in vacuum at room temperature for 48 hours to obtain a prepolymer of polysebacic anhydride; polysebacic anhydride with a molar ratio of 1:1.5 Add the prepolymer and D, L-lactic acid into the reaction vessel, react at 140°C and 0.1MPa vacuum for 60 minutes, add acetic anhydride, reflux for 40 minutes, evaporate the acetic anhydride and the generated acetic acid under reduced pressure, add toluene to dissolve and cool the heavy Crystallize, w...

Embodiment 2

[0044] The device and operation are the same as in Example 1, except that sebacic acid is replaced by adipic acid.

Embodiment 3

[0046] The device and operation are the same as in Example 1, except that sebacic acid is replaced by octadecanedioic acid.

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PUM

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Abstract

The invention relates to a biodegradable polyanhydride copolymer whose aqueous solution has temperature-sensitive in-situ gel properties, a temperature-sensitive hydrogel system of the polyanhydride copolymer and its application. Biodegradable polyanhydride copolymers are BAB, ABA or (AB)n-type amphiphilic block copolymers composed of polyethylene glycol (B) as a hydrophilic block and degradable polyanhydride (A) as a hydrophobic block objects, where n is between 1 and 50. The mass content of the polyethylene glycol block is 20% to 70%, and the mass content of the polyanhydride block is 30% to 80%. The amphiphilic block copolymer proposed in the present invention can biodegrade in vivo, and the degradation product Non-toxic and harmless, it is a new type of artificially synthesized polymer temperature-sensitive hydrogel material, which is simple and convenient to operate, and can provide a suitable drug delivery system and drug delivery method for drug injection positioning drug preparations and controlled release of drugs. It can provide gel matrix and effective means for enzyme immobilization, cell culture, tissue engineering, etc.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and their applications, and in particular relates to a temperature-sensitive biodegradable polyanhydride copolymer and its hydrogel system and applications. technical background [0002] In situ gel (in situ gel) refers to a solution system of a class of polymer materials, which spontaneously undergoes a phase transition due to changes in environmental conditions such as temperature, ionic strength, or pH, and changes from a fluid state to a semi-solid solid state. Glue state. The polymer aqueous solution or aqueous liquid in situ gel system has a hydrophilic three-dimensional network structure, good tissue compatibility, drug loading and good controlled release performance. At the same time, the unique solution-gel transition properties make it have Due to the advantages of simple preparation, convenient use, strong affinity with the drug site, especially mucosal tissue, and long resid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08J3/075A61K47/34A61K9/00
Inventor 董岸杰邓联东张金伟
Owner TIANJIN UNIV
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