Process for producing (e)-3-dimethoxy-4'-acetoxy diphenyl ethylene

Abstract

The invention discloses a method for preparing veralkalcohol derivative-(E)-3, 5-dimethoxyl-4'-acetoxyl distyrene. The method depicts Me3SiCl catalyzed by Lewis acid and Ni (acac) 2 to alkenylate 4-acetoxyl benzyl zinc bromide and 3, 5-dimethoxyl benzaldehyde to prepare veralkalcohol derivative-(E)-3, 5-dimethoxyl-4'-acetoxyl distyrene. The method comprises the procedures as follows: first, preparing 4-acetoxyl benzyl bromide, second, preparing 4-acetoxyl benzyl zinc bromide, third, preparing (E)-3, 5-dimethoxyl-4'-acetoxyl distyrene. The character of the invention is that the final product is trans-distyrene compound, the reaction product is single, the raw material is easily obtained, the cost is low, the reaction period is short, the efficiency is high, and the pollution discharge is light and is friendly for environment.

Description

technical field [0001] The present invention relates to the method for preparing resveratrol derivative-(E)-3,5-dimethoxy-4'-acetoxystilbene. Background technique [0002] (E)-3,5-dimethoxy-4'-acetoxystilbene is a derivative of resveratrol and a key intermediate for the preparation of resveratrol. Resveratrol has a variety of pharmacological activities, such as antibacterial, anti-oxidation, anti-cancer, anti-platelet aggregation, prevention of heart disease, liver protection, estrogen effect, radiation protection, immune regulation, anti-AIDS activity, etc., and can also repair atypical Cellular DNA damage induced by prescriptions for pneumonia. Resveratrol can inhibit the activity of various enzymes or cytokines, inhibit leukotriene B 4 Produces anti-inflammatory effects and inhibits prostaglandin H 2 Synthetase, reductase I, protein kinase, tumor cell necrosis factor, etc. play an anti-tumor effect. Most importantly, resveratrol has no damage to normal human cells, ha...

AI Technical Summary

Problems solved by technology

At present, there are three main ways to obtain resveratrol (1) plant extraction method, which affects the ecological environment, high cost, and small production capacity; (2) biological fermentation method or transgenic method, which has a long production cycle, complicated process, And be difficult for making required enzyme; (3) chemical synthesis method, sum up and mainly contain three kinds of methods, i.e. Witting reaction, Heck reaction and Perkin reaction, Witting reaction condition is simple and gentle, raw material is easy to get, but route is long, consumes big, The cost is high, the pollution is large, and the products generated are cis-trans diolefins, and the products are relatively complicated; the Heck reaction route is short, and the product configuration is single, but the raw materials must undergo multi-step reactions and are difficult to obtain; the Perkin reaction route is long and the cost is relatively high. high

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