Preparation of cefixime cephalosporin and fine purification method

A technology of cefixime and a refining method, applied in the field of oral cephalosporins, can solve the problems of low reaction process stability, uneven product quality, inconvenient industrialized production, etc., and achieve considerable economic benefits, good product quality and convenience The effect of industrial production
CN101220040AInactive Publication Date: 2008-07-16四川方向海瑞实业有限责任公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
四川方向海瑞实业有限责任公司
Publication Date
2008-07-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation and refining method for cefixime, which is conducted as in the following technical steps: the first step, cefixime methyl triethyl amine salt is dissolved in an organic solvent, filtered and washed after reaction with formic acid anhydrous and 98 percent of concentrated sulfuric acid below 0 DEG C, and dried in vacuum at 50 DEG C to obtain cefixime monohydrate monosulphate; the second step, the cefixime monohydrate monosulphate is dissolved in deionized water below 0 DEG C, the pH value is adjusted by ammonia, after being discolored and filtrated by activated carbon, the filtrate is added with ethanol and then 4mol / L of hydrochloride is used for adjusting the pH value, and after filtering, washing by icing water and drying at 30 DEG C in vacuum, cefixime trihydrate acid products are obtained. The method has the advantages of simple operation, little pollution, low manufacturing cost, good quality of prepared cefixime, great convenience for industrialization manufacturing and substantial economic benefits. Simultaneously, as the product of cefixime is presented as white powder with content over 98 percent, guarantees are provided for safe medication in the quality of medicines.
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Description

technical field

[0001] The present invention relates to an oral cephalosporin, specifically, the present invention relates to cefixime, namely (6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2- (Carboxymethoxyimino)]acetamido]-8-oxo-3-ethylene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate and the preparation and purification method of the compound. Background technique

[0002] Cefixime is the third-generation oral cephalosporin, which plays a bactericidal effect by inhibiting the synthesis of bacterial cell walls. It is stable to most β-lactamases. Many strains producing penicillinase and cephalosporinase are still sensitive to this product. Cefixime is effective against Gram-positive cocci such as pneumococcus and Streptococcus pyogenes in vitro and in vivo, Gram-negative bacilli such as influenza bacilli (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains), large intestine Bacillus, Proteus mirabilis, and Neisseria ...

Claims

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