Chinese South China sea signal conus neurotoxin gene Lt3.1 and uses thereof

A neurotoxin, amino acid technology, applied in nervous system diseases, non-central analgesics, medical preparations containing active ingredients, etc.
CN101220089AInactive Publication Date: 2008-07-16SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2008-07-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel M-superfamily toxin gene Lt3.1 of Conus litteratus, the coding peptide sequence lt3a and the application of the peptide in preparing the tool drugs and the analgesic drugs for the Neurobiological Study. The gene is cloned from the Conus litteratus venom tube by means of constructing a cDNA library.
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Description

technical field

[0001] The present invention relates to a Chinese South China Sea signal cone snail M-superfamily toxin gene Lt3.1 and its encoded polypeptide sequence lt3a and the preparation technology of the polypeptide, and the use of the toxin in neurobiology research, ion channel drug and analgesic drug development in the application. Background technique

[0002] Cono snails belong to the mollusk phylum Gastropoda Conidae. Most of them live in shallow waters of tropical oceans, and a few live in deep waters with a water depth of several meters to more than 200 meters. They are named for their conical or taro-shaped shapes. Conus snails are relatively young organisms. Fossil records prove that the genus Conus first appeared in the Eocene (Eocene). The first large-scale speciation of snails. The second large-scale radiation of cone snails began in the Miocene (Miocene) and basically lasted until now. The formation of each cone snail species is accompanied by the evol...

Claims

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