Medicine preparation for treating insomnia and preparing method thereof

Abstract

The invention discloses a plant medical preparation for treating or improving the insomnia without side effects, addiction or dependence to the human memory disorders and a preparation method thereof; the medical preparation for treating insomnia comprises active components of the volume ratios: valerian extracts 1 to 4 portions, spine date seed extracts 14 to 24 portions and goes through the researches of pharmacodynamics, toxicology, general pharmacology, preparation process, quality inspection and stability investigation. By adopting the valerian essential oil and the spine seed date oil composed in a suitable proportion, the invention has significant effects of synergistic interaction and stabilization of the two medicines; the preparation can also improve the biological availability obviously and further improve the efficacy with the adoption of self-emulsifying releasing medicine valerian essential oil soft capsules. Study results show that the invention has the advantages of great safety, marked or improvement effect for the insomnia, simple process, good maturity and stability; by particularly adopting a self-emulsifying medicine releasing system, the invention which can reduce doses, reduce the cost and has great actual application values is characterized by safety, rapid availability, high efficiency, convenience, beautiful exterior and stable quality.

Description

technical field [0001] The invention relates to a medicinal preparation for treating insomnia and a preparation method thereof. Specifically, it is a pure natural plant medicine prepared from Chinese herbal medicine, and the invention also relates to a preparation method of the medicine preparation. Background technique [0002] Insomnia, called neurasthenia in modern medicine, is a common clinical disease. Patients with mild symptoms manifest dizziness, pain, swelling, insomnia, dreaminess, memory loss, inattention, emotional instability, palpitation, hyperhidrosis, loss of appetite, etc. Severely ill patients may have severe sleep disturbances, even sleepless nights, marked decline in concentration and memory, depressed mood, listlessness, irritable temperament, can't bear any stimulation and are easily irritated. Uneasy, very painful, seriously affecting people's quality of life and work. Gallup survey statistics in 1995 had 49% of adults in the United States suffer fro...

AI Technical Summary

Problems solved by technology

Although benzodiazepine hypnotics can make patients fall asleep, they can change the natural sleep of insomnia patients, and the phenomenon of hangover is more serious, which is difficult to meet the needs of patients. It mainly inhibits the function of the limbic system of the brain and leads to sleep. The limbic system of the brain is accompanied by emotional activities. Parts that are closely related to memory activity, therefore, this type of drug may have side effects on human memory impairment

The main side effects of this class of drugs are sequelae, rebound sleep disorders, and drug resistance; while another class of drugs is non-benzodiazepines such as zopiclone, and its side effects are mainly central nervous system such as memory loss, nervous system, etc. Syndrome, mental depression and movement disorders etc.

[0004] In addition, chloral hydrate is irritating to the gastrointestinal tract, and patients who take the drug sometimes have skin rashes. Long-term use of chloral hydrate can lead to drug dependence; excessive use of chlormethiazole can inhibit breathing and produce drug dependence; antihistamines can only Occasionally use it once or twice, and it is not suitable for frequent use; benzodiazepines were developed and marketed in the late 1970s and are the most widely used sleeping pills in the world so far. People who take the drugs are prone to drowsiness during the day, which affects their work. Patients who take them for a long time Once the drug is stopped, symptoms such as delirium, epileptic seizures, tremor, sweating, and loss of appetite will appear, and drug tolerance will develop in a short period of time after taking the drug

In the late 1980s, a hypnotic drug "Zobiclone" with a new chemical structure was developed and marketed abroad. Because of drug resistance, it is not suitable for continuous use.