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Ophthalmic composition containing natamycin, use and preparation method thereof

An ophthalmic composition and a technology of natamycin, applied in the field of medicine and health, can solve problems such as ineffectiveness, and achieve the effects of improving compliance, convenient and quick use, and simple medication

Inactive Publication Date: 2008-10-08
SHANDONG BAUSCH & LOMB FREDA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natamycin has no effect on Gram-positive and Gram-negative bacteria in vitro

Method used

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  • Ophthalmic composition containing natamycin, use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Natamycin

[0032] Take 50ml of water, add sodium hydroxide to dissolve, add natamycin, stir at high speed, add 2mol / L hydrochloric acid solution, get natamycin solution; take another appropriate amount of water, add sodium hyaluronate, hypromellose, Dissolve glycerin, sodium sulfite, benzalkonium chloride, tobramycin, disodium edetate, polysorbate 80, mix with natamycin solution, adjust pH to about 7.0 with hydrochloric acid or sodium hydroxide, add water to total volume, Sterilized by circulating steam for 30 minutes.

Embodiment 2

[0034] Natamycin

[0035] Take 50ml of water, add sodium hydroxide to dissolve, add natamycin, stir at high speed, add 2mol / L hydrochloric acid solution, get natamycin solution; take another appropriate amount of water, add povidone K90, sodium chloride, sodium sulfite, Dissolve benzalkonium chloride, neomycin sulfate, and edetate disodium, mix with natamycin solution, adjust the pH to about 7.0 with hydrochloric acid or sodium hydroxide, add water to the total volume, and sterilize with circulating steam for 30 minutes to obtain .

Embodiment 3

[0037] Natamycin

[0038] Take 50ml of water, add sodium hydroxide to dissolve, add natamycin, stir at high speed, add 2mol / L hydrochloric acid solution, get natamycin solution; take another appropriate amount of water, add povidone K90, sodium dihydrogen phosphate, sodium sulfite , benzalkonium chloride, ofloxacin, and disodium edetate were dissolved, mixed with natamycin solution, adjusted to about 7.0 with hydrochloric acid or sodium hydroxide, replenished with water to the total volume, and sterilized by circulating steam for 30 minutes. have to.

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PUM

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Abstract

The invention discloses an ophthalmic composition containing natamycin, a usage and a preparation method; the composition contains: a) the natamycin, wherein, concentration of the natamycin is an effective antifungal concentration in eye region of mammals; b) one or a plurality of antimicrobial drugs, wherein, the concentration is the effective antifungal concentration in the eye region of mammals; c) ophthalmic adjuvant. The preparation method is characterized in that the composition is changed together with at least one liquid or semi-liquid carrier or adjuvant into an applicable ophthalmic medicament form. The usage of the composition is that ophthalmic preparation which is used for treating and preventing the concurrent infection of bacterium and fungi in the eye region is prepared. The medicinal composition of the invention is capable of playing an antibacterial and antifungal role and avoiding untoward effect such as contraindication, irritation and allergy caused by unilateral medication.

Description

Technical field [0001] The present invention relates to the technical field of medicine and health, and is specifically an ophthalmic composition containing natamycin for treating and preventing ocular fungal and bacterial combined infections. Background technique [0002] Fungal keratitis or corneal mycosis is difficult to diagnose clinically and is easily misdiagnosed. It often causes blindness due to improper treatment. Fungal keratitis is not uncommon. A large proportion of cases of so-called "creeping corneal ulcers" that do not respond to antibiotic treatment may be caused by fungal infections. In terms of incidence, the incidence rate is higher in the south than in the north; the incidence rate is higher during the busy farming seasons of summer and autumn. In terms of age and occupation, it is more common in young adults, the elderly and farmers. [0003] Normally, fungi will not invade the normal cornea. However, non-pathogenic fungi can become invasive when the ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/00A61K31/7048A61K45/06A61P27/02
Inventor 凌沛学贺艳丽白若琬李永春万秀玉张青潘继飞荣晓花
Owner SHANDONG BAUSCH & LOMB FREDA PHARM CO LTD
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