Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicament automatic release system preparation method based on conductive polymer polypyrrole

A conductive polymer, self-release technology, applied in non-active ingredient medical preparations, pharmaceutical formulations, drug delivery, etc., can solve problems such as increased energy consumption, complicated processing and sealing, etc.

Inactive Publication Date: 2011-08-10
XIAMEN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current drug release system using polypyrrole as a drug carrier requires a certain potential to release the drug. Therefore, only when the power supply is integrated in the system can it meet the requirements of its release in the body.
This not only increases energy consumption, but also complicates processes such as processing and sealing, which limits the further application of polypyrrole drug release technology to a certain extent.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Pretreatment of titanium sheet

[0021] Set the area to 150mm 2 , a titanium sheet with a thickness of 0.5 mm was ultrasonically treated with toluene, acetone, and absolute ethanol for 10 min, respectively, soaked in hydrofluoric acid for 30 s, and then ultrasonically treated with absolute ethanol for 10 min, and then removed with N 2 blow dry.

[0022] 2) One-side sealing of titanium sheet

[0023] One surface of the pretreated titanium sheet is sealed with insulating material epoxy resin.

[0024] 3) Immobilization of sulfosalicylic acid

[0025] The titanium sheet sealed on one side is immersed in an aqueous solution composed of pyrrole monomer (0.02mol / L) and sulfosalicylic acid (0.02mol / L), with the titanium sheet as the working electrode and the platinum electrode as the auxiliary electrode, saturated The calomel electrode was used as a reference electrode. At a polymerization potential of 1.1V, a polypyrrole film immobilized with sulfosalicylic acid was gr...

Embodiment 2

[0031] 1) Pretreatment of titanium sheet

[0032] Set the area to 140mm 2 , a titanium sheet with a thickness of 0.8 mm was ultrasonically treated with toluene, acetone, and absolute ethanol for 10 min, respectively, soaked in hydrofluoric acid for 30 s, and then ultrasonically treated with absolute ethanol for 10 min, and then removed with N 2 blow dry.

[0033] 2) One-side sealing of titanium sheet

[0034] One surface of the pretreated titanium sheet is sealed with insulating material epoxy resin.

[0035] 3) Immobilization of sulfosalicylic acid

[0036] The titanium sheet sealed on one side is immersed in an aqueous solution composed of pyrrole monomer (0.08mol / L) and sulfosalicylic acid (0.04mol / L), with the titanium sheet as the working electrode and the platinum electrode as the auxiliary electrode, saturated The calomel electrode was used as a reference electrode. At a polymerization potential of 850mV, a polypyrrole film immobilized with sulfosalicylic acid was g...

Embodiment 3

[0042] 1) Pretreatment of titanium sheet

[0043] Set the area to 120mm 2 , a titanium sheet with a thickness of 1.0 mm was ultrasonically treated with toluene, acetone, and absolute ethanol for 10 min, respectively, soaked in hydrofluoric acid for 30 s, and then ultrasonically treated with absolute ethanol for 10 min, and then removed with N 2 blow dry.

[0044] 2) One-side sealing of titanium sheet

[0045] One surface of the pretreated titanium sheet is sealed with insulating material epoxy resin.

[0046] 3) Immobilization of sulfosalicylic acid

[0047] Immerse the titanium sheet sealed on one side in an aqueous solution composed of pyrrole monomer (0.15mol / L) and sulfosalicylic acid (0.05mol / L), use the titanium sheet as the working electrode, and the platinum electrode as the auxiliary electrode. The calomel electrode was used as a reference electrode. At a polymerization potential of 800mV, a polypyrrole film immobilized with sulfosalicylic acid was grown on the un...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
areaaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of an automatic drug release system based on electric conduction macromolecule polypyrrole and relates to a release technology of drug control, The invention provides a preparation method of the automatic drug release system based on electric conduction macromolecule polypyrrole, with polypyrrole as a drug carrier and without additional potential to automatically release the drug sulfosulicylic acid under body temperature. Surface insulating material of a pre-treated titanium sheet is sealed, and then the titanium sheet is immerged in the solution composed of pyrrole monomer and sulfosalicylic acid; polypyrrole film-supported sulfosulicylic acid is generated on the surface of the unsealed side of the titanium sheet by adopting an electrochemical method, the insulating material on the sealed side of the titanium sheet is removed and coated with a layer of eicosane, and then the final drug release system is obtained. The drug release system is placed in normal saline, phosphate buffer solution or simulated body fluid, the eicosane dissolves automatically after warming up to 36.8-37.5 DEG C, and polypyrrole film-supported sulfosulicylic acid can be automatically released to the solution successively.

Description

technical field [0001] The invention relates to a drug controlled release technology, in particular to a preparation method of a drug release system using polypyrrole as a drug carrier. Background technique [0002] Polypyrrole is a conductive polymer with unique doping / dedoping properties. When it changes between the oxidation state and the reduction state, it will be accompanied by the process of doping ions entering and leaving the conductive polymer, so as to The balance of charge is maintained (J M Pernaut, JR Reynolds, Journal of Physical Chemistry B, 2000, 104, 4080-4090). When the dopant ion is a drug, this principle can be used to realize the storage and release of the drug, so polypyrrole can be used as a carrier for drug release. At present, glutamate, adenosine triphosphate (ATP), N-methylphenothiazine, naproxen, salicylate, fluorouracil (5-Fu), furofluorouracil ( TF-207) and the reports of multiple drugs such as macromolecular nerve growth factor (AliAkbar Ent...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/48A61K31/60A61K47/30A61K47/58
Inventor 葛东涛戚汝财石巍黄三庆穆静张其清
Owner XIAMEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com