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Production process of pure amino acid chelate and use thereof

A technology of amino compounds and amino acids, which is applied in the field of amino acid chelate complexes, can solve problems such as the accumulation of sulfate anions or chloride anions and affect the health of the body, and achieve the effect of improving solubility, easy solubility, and good solubility

Inactive Publication Date: 2008-11-12
VIVA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, long-term intake of this amino acid chelate can lead to the accumulation of sulfate anions or chloride anions in the body tissues, which can negatively affect the health of the body

Method used

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  • Production process of pure amino acid chelate and use thereof
  • Production process of pure amino acid chelate and use thereof
  • Production process of pure amino acid chelate and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] 3.7923 grams of aspartic acid was dissolved in 200 mL of distilled water, 2.1100 grams of calcium hydroxide was added to the solution and stirred for 20 minutes, when the pH value was 10.30, 4.3433 grams of glycine was added to the reaction solution and stirred for 30 minutes , the measured pH value is 8.75. Finally, 3.9098 g of aspartic acid was added to the reaction solution and the reaction mixture was stirred for 40 minutes to generate a transparent solution with a pH value of 6.83 and evaporated with a rotary evaporator (Tokyo Rikakikai Co., Ltd. Eyela Digital Water Bath SB-1000) The water was removed and dried to a solid with the aid of vacuum (Gardner Denver Welch Vacuum Technology, Inc., Skokie, IL, USA. Welch 1400). The pure amino acid chelate produced by the method is tested to have a calcium-amino acid ratio of 1:4 (Ca:2Asp:2Gly). Infrared spectroscopy (FT-IR) and nuclear magnetic resonance (NMR) analysis showed that the four amino acid ligands of the amino ...

Embodiment 2

[0057] Aspartic acid (3.7912 grams) was dissolved in 200 mL of water containing calcium hydroxide (2.1094 grams) and the reaction was allowed to proceed for 20 minutes. Once the pH is 10.30 and stable add 5.9866 grams of serine and agitate until the pH drops to 8.52 and stabilizes (approximately 30 minutes). Finally, 3.7862 g of aspartic acid was added to the reaction solution and the reaction mixture was stirred for 105 minutes. Finally, a transparent solution with a pH value of 6.89 was placed in a rotary evaporator to remove water, and then dried to a solid with the help of a vacuum pump. The ratio of calcium and amino acid in the pure amino acid chelate produced by the method is 1:4 (Ca:2Asp:2Ser).

Embodiment 3

[0059] 2.1135 grams of calcium hydroxide and 3.7985 grams of aspartic acid were added to 200 mL of water to react, stirring continuously and allowing the reaction to proceed for 20 minutes. When the pH of the reaction solution reached 10.30 and became stable, 6.7999 g of threonine was added and stirred continuously for about 30 minutes until the pH decreased to 8.50 and became stable. Then, 3.8012 grams of aspartic acid was added and stirred for 120 minutes. A transparent liquid with a pH value of 6.90 was dehydrated with a rotary evaporator and further dried under a vacuum pump. The final amino acid chelate product is a white powder with a calcium to amino acid ratio of 1:4 (Ca:2Asp:2Thr).

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Abstract

The invention provides a method for producing pure amino acid chelate and use thereof. The method is as followings: the first step is to reacting oxide or metal hydroxide and the amino acid to generate hydroxyl amino acetate; the second step is to conduct a combination reaction of the hydroxyl amino acetate which is generated in the first step and at least an amino-containing compound, and the compound with abundant amino is reacted with a metal ion, thus, the generated amino acid chelate structure is formed by combining one metal ion and a plurality of ligands of the amino acid, but the number of the ligands of the amino acid is equal to the number of the ligands of the metal ion, and the pure amino acid chelate is separated from reaction generation liquid. The second step also comprises several continuous sub-steps for reaction with a plurality of amino-containing compounds. The generated pure amino acid chelate can be applied to beverage, food, health products and medicine, in particular a zinc amino acid chelate that can obviously and effectively increase a white mouse immune function with lower immunity.

Description

technical field [0001] The present invention relates to the production method and application of amino acid chelate complex. More specifically, the pure amino acid chelate produced by the present invention has very good solubility in a wide range of pH values, and the stability of the solution is also very good, and the solution stability lasts for a very long time. Background technique [0002] Supplementing the right amount of essential minerals in the daily diet is very important for maintaining human health. It is well known that, for example, calcium deficiency may cause osteoporosis, immunological diseases, hypertension, arthritis, colon cancer, diabetes, and obesity; zinc deficiency, resulting in prolonged wound healing, stunted growth, delayed sexual maturation, and pregnancy After stretch marks, fatigue, and susceptibility to infection. [0003] Metal elements chelated with amino acids are important mineral sources necessary for human animal and plant nutrition. ...

Claims

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Application Information

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IPC IPC(8): C07C229/76C07C279/14C07C323/58C07D233/64A61K31/198A61P3/00A23L1/30A23L2/52A23L33/165A23L33/175
Inventor 谢雪菊柯江忠
Owner VIVA PHARMA
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