Use of cyaniding 3-0 glucoside in preparing medicament or food for preventing and curing atrophic arthritis

A glucoside, rheumatoid technology is applied in the application field of cyanidin 3-O-glucoside in the preparation of rheumatoid arthritis drugs or food, and can solve the problem of large side effects and high incidence of drug-induced diseases problem, to achieve a good effect, good anti-inflammatory and analgesic, and inhibit the effect of adjuvant arthritis

Active Publication Date: 2008-11-19
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The side effects of western medicine treatment are large, some patients cannot tolerate them, and

Method used

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  • Use of cyaniding 3-0 glucoside in preparing medicament or food for preventing and curing atrophic arthritis
  • Use of cyaniding 3-0 glucoside in preparing medicament or food for preventing and curing atrophic arthritis
  • Use of cyaniding 3-0 glucoside in preparing medicament or food for preventing and curing atrophic arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Maximum tolerated dose test and anti-inflammatory activity test of cyanidin 3-O-glucoside

[0020] 1. Test materials: Animals: ICR mice, 18-22g, both male and female; SD rats, weighing 180-200g, male, provided by Beijing Experimental Animal Research Center.

[0021] 2. Reagent: cyanidin-3-O-glucoside (hereinafter referred to as C3G, with a purity of 95%); aspirin was purchased from Hunan Yongke Light Industrial Products Import and Export Co., Ltd.; carrageenan was purchased from China Lianxing Industrial Co., Ltd. Company; electronic analytical balance, vortex mixer.

[0022] 3. Test method: (1) Maximum tolerance test: 40 ICR mice were divided into two groups, group 1, normal water control group; group 2, C3G group. There were 20 mice in each group, half male and half male. After fasting for 12 hours, the mice were intragastrically administered with a C3G solution with a maximum concentration of 0.4 g / mL within 1 day, once every 4 hours. A total of 3 times a day, 0.30...

Embodiment 2

[0032] Analgesic activity test of cyanidin 3-O-glucoside

[0033] 1. Test materials: Animals: ICR mice, 18-22g, both male and female; provided by Beijing Experimental Animal Research Center.

[0034] 2. Reagent: cyanidin 3-O-glucoside (C3G) (cyanidin 3-O-glucoside content 95%); aspirin was purchased from Hunan Yongke Light Industrial Products Import and Export Co., Ltd.; acetic acid was of analytical grade , electronic analytical balance, vortex mixer.

[0035] 3. Test method: (1) Acetic acid writhing test: 50 mice, half male and half male, were randomly divided into 5 groups, respectively administered with drugs or the same amount of water, and 1 hour after the drug, each mouse was intraperitoneally injected with 0.7% HAC physiological salt 0.2ml aqueous solution, observe the number of writhing reactions in mice within 20 minutes after injection of HAC, and calculate the analgesic inhibition percentage.

[0036]

[0037] (2) Mouse hot plate test: test according to Zhao Y...

Embodiment 3

[0046] Anti-adjuvant rheumatoid arthritis effect of cyanidin-3-O-glucoside

[0047] 1. Test materials: Animals: ICR mice, 18-22g, both male and female; SD rats, weighing 180-200g, male, provided by Beijing Experimental Animal Research Center.

[0048]2. Reagents: cyanidin-3-O-glucoside (purity: 95%); complete Freund's adjuvant, product of Sigma Company; dexamethasone injection, electronic analytical balance, vortex mixer.

[0049] 3. Test method: get 48 male rats, body weight 160~180g, divide into 6 groups randomly according to body weight, be respectively control group (NS 10mI / kg); Model group (NS 10mI / kg); Dexamethasone group ( 0.85mg / kg); C3G medium and high dose (25, 50, 100mg / kg) groups. Each group was administered ig once a day for 24 consecutive days. After the start of the experiment, the volume of the left and right hind paws was measured by the volumetric method, and then 1 hour after administration on the first day, except for the control group, 0.1 mL of SC Freu...

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Abstract

The invention discloses the application of cyaniding 3-O-glucoside to the preparation of drugs or foods for preventing and controlling rheumatoild disease. The cyaniding 3-O-glucoside has better abirritation and acute inflammation resistance functions, and more importantly has the function of resisting the adjuvant-induced rheumatoild disease. A cytology experiment in vitro shows that the cyaniding 3-O-glucoside can inhibit the NO release of macrophage, thereby showing that the functions of anti-inflammation, analgesic effect and adjuvant-induced rheumatoild disease resistance are mainly derived from the strong inhibiting ability. The multiple effects of the cyaniding 3-O-glucoside lead the advantages on the aspect of controlling the rheumatoild disease to be more obvious. The cyaniding 3-O-glucoside is derived from wholefood, is efficient and innoxious, has extremely high safety, and thus has wide application prospect for controlling the rheumatoild disease in clinic.

Description

technical field [0001] The invention relates to the application of cyanidin 3-O-glucoside in preparing medicine or food for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic systemic autoimmune disease mainly characterized by joint lesions. It belongs to the category of Bi syndrome in traditional Chinese medicine. "Stubborn numbness" and so on are similar. RA is characterized by recurrent attacks and high disability rate. It is a common and refractory disease. At present, there is no effective treatment at home and abroad[1]. Western medicine has many side effects, some patients cannot tolerate it, and the incidence of drug-induced diseases caused by inappropriate western medicine is higher. Traditional Chinese medicine not only has a wide range of sources, a large number of types, and small toxic and side effects, but also has the characteristics of multi-link, multi-level, and multi-ta...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P29/00A61P19/02A61P19/04
Inventor 刘丹刘岱琳於洪建
Owner 天津市尖峰天然产物研究开发有限公司
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