Method for preparing L-ascorbate-2-phosplate magnesium

Abstract

The invention relates to a preparation method for L-ascorbic acid-2-monophosphate ester magnesium. The method which adopts no organic solvent during the preparation process does not cause environmental pollution with simple after treatment and high purity of the prepared L-ascorbic acid-2-monophosphate ester magnesium. The method is characterized in that: water, L-ascorbic acid and calcium chloride are added into a reaction kettle with a temperature between -5 DEG C and 10 DEG C for agitation, then 20-60 percent of sodium hydroxide or calcium hydroxide aqueous solution is added slowly into the reaction kettle, a PH value is regulated to 6-9.5, and sodium trimetaphosphate with a dosage of 0.8-1.5 folds of vc is added into the reaction kettle with the temperature being kept between 15 DEG C and 35 DEG C; the reaction products are washed by water, the PH value is regulated to 0.5-3.0 through hydrochloric acid, sulphuric acid or oxalic acid, then filtration is carried out, and filtrate liquor passes through weak anion resin and is eluted in turn by 0.02m hydrochloric acid and 0.2-0.8m hydrochloric acid; magnesia is used to regulate the PH value of an eluted part which is filtrated to remove deposit, filtrate liquor is decompressed and condensed to 1/5 of the original volume at a temperature of 40 DEG C, ethanol with a volume being 2-4 folds of that of the condensed filtrate liquor and a content of 95 percent is added, and then crushing and drying is carried out after crystallization, centrifugal collection and washing.

Description

(1) Technical field The invention relates to a preparation method of L-ascorbic acid derivatives, in particular to a preparation method of L-ascorbic acid-2-monophosphate magnesium. (2) Background technology L-ascorbic acid (vitamin C, hereinafter referred to as VC) has a chemical structural formula as an acidic enol-structured lactone, which exists in fresh vegetables and fruits in nature, and is a kind necessary for the human body. vitamins. VC has been widely used in medicine, food, cosmetics and animal breeding and other fields. But VC its C 2 、C 3 The hydrogen of the enolate hydroxyl group is easy to dissociate, and it is easily oxidized into dehydrovitamin C by air and other oxidants, and will soon undergo an irreversible decomposition reaction and lose the VC reducing ability. It is found that the activity of VC is mainly derived from the two hydroxyl groups on its enol structure. If any of the hydroxyl groups is esterified with inorganic acids, the stability to h...

AI Technical Summary

Problems solved by technology

In view of the above problems, the present invention provides a preparation method of L-ascorbic acid-2-magnesium monophosphate, which does not need to use organic solvents in th

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